KORELASI ANTARA RESISTENSI ANTIMIKROBA DENGAN KEMAMPUAN MEMBENTUK BIOFILM PADA ISOLAT PSEUDOMONAS AERUGINOSA DARI SAMPEL SPUTUM ETT DI RUANG RAWAT INTENSIF RSUD DR. SAIFUL ANWAR

Ruliatna, Etty Fitria
Ruliatna, Fitria
Trisnawati, Lydia
Kusumaningrum, Yuyun

Jurnal Klinik dan Riset Kesehatan
Vol 5 No 2 (2026): Volume 5 No 2, Edisi Februari 2026

Background: Pseudomonas aeruginosa is a prominent pathogen responsible for hospital-acquired infections. Its pathogenic potential is primarily driven by antimicrobial resistance and the ability to form biofilms. Aim: To examine the correlation between antimicrobial resistance patterns and the biofilm-forming ability of Pseudomonas aeruginosa isolated from endotracheal tube (ETT) sputum specimens. Methods: This analytic cross-sectional study used sputum samples from ICU patients with ETT. Biofilm detection was done using the microtiter plate method, and antimicrobial susceptibility was tested using Vitek. Results: Of the 23 multidrug-resistant (MDR) isolates identified, 45.5% demonstrated biofilm-forming ability, while 54.5% did not. Statistical analysis using the Chi-square test revealed no significant association between antimicrobial resistance and biofilm formation. Conclusion: There was no significant correlation between multidrug resistance and biofilm production in Pseudomonas aeruginosa isolates from ETT sputum samples.