The security and integrity of medical record data is a crucial issue in the era of healthcare service digitalization. Traditional systems still face risks of manipulation, information leaks, and issues with interoperability between healthcare institutions. Blockchain technology has emerged as a promising solution to address this issue thanks to its features of decentralization, openness, and difficulty in modification. One consensus method that can be applied is Proof of Work (PoW), which has proven to maintain the authenticity of transactions on a distributed network. This research aims to design and evaluate a blockchain-based medical record application using the PoW consensus algorithm to ensure the security, transparency, and reliability of medical data storage. The approach used is experimental, involving the development of a blockchain-based application prototype. The PoW algorithm is applied to ensure the validity of medical record data transactions. The evaluation was conducted by measuring the security aspect (resistance to data changes), performance (time to verify transactions), and scalability (number of transactions that can be handled). The results of the experiment show that implementing PoW in a medical record system can maintain data integrity with a high level of resistance to unauthorized changes. The average time for transaction verification is 2.4 seconds per block, with the ability to handle up to 150 transactions per minute. Although the performance of PoW requires significant computational resources, the level of security it offers suggests potential for implementation in larger healthcare systems. The application of blockchain with the PoW algorithm to medical records has proven to improve the security and transparency of medical information. This research successfully met the established objectives, although computational efficiency issues still need to be addressed. Further research is suggested to explore other consensus algorithms such as Proof of Stake (PoS) or Practical Byzantine Fault Tolerance (PBFT) to improve performance without sacrificing security aspects. Keywords: Blockchain, Electronic Health Records (EHR), Proof of Work (PoW), Smart Contract, Healthcare Information System
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