Caffeine is the most widely consumed psychoactive substance in the world and has stimulating effects on the central nervous system. It is commonly used to enhance alertness and performance. However, excessive consumption may lead to negative effects such as sleep disturbances, anxiety, and dependence. This study aims to analyze the effect of caffeine consumption on human physiological responses, particularly stimulation and dependence.This study used a quantitative cross-sectional design with 60 respondents selected through purposive sampling. Data were collected using validated questionnaires and analyzed using Chi-Square and logistic regression tests.The results showed that 58.3% of respondents had high caffeine consumption, 63.3% experienced high stimulation, and 56.7% showed dependence. There was a significant relationship between caffeine consumption and stimulation (p=0.002) as well as dependence (p=0.001). Logistic regression analysis revealed that caffeine consumption was the most dominant factor influencing dependence (OR=5.21).In conclusion, caffeine has beneficial stimulatory effects but excessive consumption increases the risk of dependence.
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