<![CDATA[Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Tithonia diversifolia (Kipahit) leaves are traditionally used for diabetes. This study aims to determine the antidiabetic effectiveness of Kipahit leaf ethanol extract on blood glucose levels in streptozotocin (STZ)-induced diabetic rats. The research was an experimental laboratory study using a post-test only control group design. Thirty male rats were divided into six groups: normal control, negative control (STZ), positive control (STZ + metformin), and three treatment groups receiving the extract at doses of 250, 350, and 450 mg/kg BW. The extract yield was 29.67%. Phytochemical screening showed positive results for flavonoids, alkaloids, saponins, tannins, and steroids. Blood glucose levels were measured on days 0, 3, 6, 9, 12, and 15. Data were analyzed using One-Way ANOVA and Duncan's post hoc test. The results showed that the extract significantly reduced blood glucose levels. The dose of 450 mg/kg BW was the most effective, with an effect comparable to metformin.]]>
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