Garuda - Garba Rujukan Digital

Antihyperuricemia Effectiveness Test of Ethanol Extract of Kedondong Pagar Leaves (Lannea coromandelica (Houtt.) Merr.) Against Male White Rats (Ratus norvegicus) Nasution, Irma Suryani; Siregar, Anggie Patrisia; Br Ginting, Astriani Natalia; Kaban, Vera Estefania; Siagian, Roy Indrianto Bangar
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 4 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i03.137

Hyperuricemia is a metabolic disorder caused by elevated serum uric acid levels that may progress to gout and other complications. Although synthetic drugs such as allopurinol are effective, their long-term use may cause adverse effects, thus alternative therapies derived from natural products are needed. This study aimed to evaluate the antihyperuricemic activity of the ethanol extract of kedondong pagar leaves (Lannea coromandelica (Houtt.) Merr.) in male white rats (Rattus norvegicus). An in vivo experimental study was conducted using potassium oxonate–induced hyperuricemic rats. The animals were divided into five groups: negative control (0.5% CMC), positive control (allopurinol 10 mg/kgBW), and three treatment groups receiving the ethanol extract at doses of 100, 200, and 300 mg/kgBW. Serum uric acid levels were measured before induction, after induction, and hourly up to six hours following treatment. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides in the extract. The results demonstrated that the ethanol extract of Lannea coromandelica leaves significantly reduced serum uric acid levels in a dose-dependent manner, with the 300 mg/kgBW dose showing the greatest effect and approaching the efficacy of allopurinol. In conclusion, the ethanol extract of kedondong pagar leaves has potential as a natural antihyperuricemic agent.

EFEKTIVITAS GEL DAUN KIPAHIT (Tithonia diversifolia) TERHADAP PENYEMBUHAN LUKA DIABETES PADA TIKUS Khadijah, Siti; Br Ginting, Astriani Natalia; Simanjuntak, Nerly Juli Pranita
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1614

Diabetes mellitus is a chronic disease commonly associated with complications such as diabetic wounds, which are characterized by impaired tissue perfusion, prolonged inflammation, and increased susceptibility to infection, resulting in delayed wound healing. Although various topical therapies have been developed, the use of herbal-based formulations for diabetic wound management remains an area of ongoing research. Leaves of Tithonia diversifolia are known to contain secondary metabolites such as flavonoids, tannins, alkaloids, and saponins, which may support the wound healing process. This study aimed to evaluate the effectiveness of Tithonia diversifolia leaf extract gel on wound healing in streptozotocin (STZ)-induced diabetic rats. This experimental study used 30 male white rats divided into six groups: normal control, negative control (gel base), positive control (octeniline gel), and treatment groups receiving Tithonia diversifolia extract gel at concentrations of 5%, 10%, and 15%. The extract was obtained by maceration using 70% ethanol and formulated into a topical gel. Wound length was observed on days 0, 3, 7, and 14, and the data were analyzed using One-Way ANOVA followed by Tukey HSD test. The results showed that Tithonia diversifolia extract gel significantly affected wound healing from day 3 to day 14 (p < 0.05). The 10% and 15% formulations demonstrated better wound healing than the negative control, while the 15% formulation showed the most optimal result, with a mean wound length of 0.40 mm on day 14. Therefore, Tithonia diversifolia extract gel has potential to be developed as a topical preparation supporting wound healing under diabetic conditions.

UJI EFEKTIVITAS ANTIDIABETIK DAUN KIPAHIT (Tithonia diversifolia) TERHADAP KADAR GLUKOSA DARAH PADA TIKUS MODEL DIABETES TERINDUKSI STREPTOZOTOCIN Hasanah, Nurul; Br Ginting, Astriani Natalia; Yunus, Muhammad
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1615

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Tithonia diversifolia (Kipahit) leaves are traditionally used for diabetes. This study aims to determine the antidiabetic effectiveness of Kipahit leaf ethanol extract on blood glucose levels in streptozotocin (STZ)-induced diabetic rats. The research was an experimental laboratory study using a post-test only control group design. Thirty male rats were divided into six groups: normal control, negative control (STZ), positive control (STZ + metformin), and three treatment groups receiving the extract at doses of 250, 350, and 450 mg/kg BW. The extract yield was 29.67%. Phytochemical screening showed positive results for flavonoids, alkaloids, saponins, tannins, and steroids. Blood glucose levels were measured on days 0, 3, 6, 9, 12, and 15. Data were analyzed using One-Way ANOVA and Duncan's post hoc test. The results showed that the extract significantly reduced blood glucose levels. The dose of 450 mg/kg BW was the most effective, with an effect comparable to metformin.

FORMULASI SEDIAAN MASKER GEL PEEL OFF EKSTRAK DAUN SIRIH CINA (PEPEROMIA PELLUCIDA) Nasution, Nurul Mawaddah; Br Ginting, Astriani Natalia; Yunus, Muhammad
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1622

Acne vulgaris is a common skin disorder often associated with increased sebum production and colonization of Cutibacterium acnes on the skin. Peperomia pellucida L. is a medicinal plant known to contain secondary metabolites such as flavonoids, alkaloids, saponins, and tannins, which have potential for use in the development of natural cosmetic formulations. This study aimed to formulate Peperomia pellucida leaf extract into a peel-off gel mask preparation and evaluate its physical characteristics. The extraction of the leaves was carried out using a maceration method with 96% ethanol as the solvent. The obtained extract was then formulated into four different concentrations (0%, 2%, 4%, and 6%) using a gel base consisting of polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), triethanolamine (TEA), glycerin, nipagin, nipasol, and distilled water. The evaluation of the formulations included organoleptic observation, homogeneity test, pH measurement, drying time, and spreadability test. The results showed that all formulations produced homogeneous preparations with pH values ranging from 5.75 to 6.20, drying time between 15–25 minutes, and spreadability ranging from 6.3 to 6.8 cm. Increasing extract concentration affected the organoleptic characteristics and drying time of the preparations. Based on the physical evaluation results, the formulation containing 4% extract demonstrated the most optimal physical characteristics compared with the other formulations.

UJI AKTIVITAS ANTIOKSIDAN TERHADAP EKSTRAK ETANOL DAUN MANGGA ARUM MANIS (Mangifera indica L. var. arum manis) MENGGUNAKAN METODE DPPH Mahzura, Siti; Br Ginting, Astriani Natalia; Harahap, Daimah Wirdatus Sanaun
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1624

Radikal bebas dapat memicu stres oksidatif yang berperan dalam berbagai penyakit degeneratif, sehingga diperlukan sumber antioksidan alami yang aman dan efektif. Daun mangga arum manis mengandung berbagai senyawa bioaktif seperti flavonoid, alkaloid, tanin, saponin, dan triterpenoid yang berpotensi sebagai antioksidan. Tujuan penelitian ini adalah mengetahui aktivitas antioksidan ekstrak etanol daun mangga arum manis (Mangifera indica L. var. arum manis) menggunakan metode DPPH (2,2-diphenyl-1-picrylhydrazyl). Metode penelitian yang digunakan adalah eksperimen laboratorium. Daun mangga dikumpulkan dari Kecamatan Secanggang, Kabupaten Langkat, kemudian dideterminasi di Herbarium Medanense. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 96%. Skrining fitokimia dilakukan untuk mengidentifikasi kandungan metabolit sekunder. Uji aktivitas antioksidan dilakukan menggunakan variasi konsentrasi ekstrak 20, 40, 60, 80, dan 100 ppm serta vitamin C sebagai kontrol positif. Sampel direaksikan dengan larutan DPPH 50 ppm dan absorbansi diukur pada panjang gelombang 517 nm setelah inkubasi 30 menit. Hasil penelitian menunjukkan bahwa persentase inhibisi meningkat seiring peningkatan konsentrasi ekstrak, dengan nilai inhibisi tertinggi sebesar 50,2% pada konsentrasi 100 ppm. Analisis regresi linear menghasilkan nilai IC₅₀ sebesar 98,73 ppm yang termasuk kategori aktivitas antioksidan kuat. Sebagai pembanding, vitamin C menunjukkan nilai IC₅₀ sebesar 6,07 ppm yang mengindikasikan aktivitas antioksidan sangat kuat. Kesimpulan penelitian ini adalah bahwa ekstrak etanol daun mangga arum manis memiliki aktivitas antioksidan kuat berdasarkan nilai IC₅₀. Meskipun potensinya lebih rendah dibandingkan vitamin C, ekstrak ini tetap menunjukkan kemampuan signifikan sebagai sumber antioksidan alami. Penelitian lanjutan disarankan menggunakan metode FRAP atau ABTS untuk memperkuat hasil.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MANGGA ARUM MANIS (Mangifera indica L. ‘Arumanis’) TERHADAP Staphylococcus aureus Alya, Cinta; Br Ginting, Astriani Natalia; Harahap, Daimah Wirdatus Sanaun
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1625

The increasing prevalence of bacterial resistance to antibiotics has encouraged the exploration of natural products as alternative antimicrobial agents. This study aimed to evaluate the inhibitory potential of the ethanolic extract of ‘Arumanis’ mango leaves (Mangifera indica L. ‘Arumanis’) against Staphylococcus aureus ATCC 25923. The research was conducted using a laboratory experimental design including plant identification, preparation of simplicia, extraction by maceration with 96% ethanol, phytochemical screening, and antibacterial activity testing using the disk diffusion method. The extract was tested at concentrations of 5%, 10%, and 15% (50–150 mg/mL), with three replications (n=3) for each treatment and control group. The inhibition zones were measured including the 6 mm disk diameter and analyzed descriptively as mean ± standard deviation. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids. The antibacterial assay showed inhibition zone diameters of 3.00 ± 2.12 mm (5%), 4.38 ± 2.51 mm (10%), and 6.13 ± 2.63 mm (15%), while the positive control chloramphenicol (30 µg/disk) produced a 21.43 ± 0.06 mm inhibition zone and the negative control (10% DMSO) showed no inhibitory effect. Although inhibition zones were observed at all concentrations, the diameters were relatively small compared to the standard antibiotic. Therefore, the ethanolic extract of M. indica ‘Arumanis’ leaves demonstrates concentration-dependent inhibitory potential against S. aureus, but with limited antibacterial activity, indicating the need for further evaluation using dilution methods to determine the Minimum Inhibitory Concentration (MIC).

FORMULASI MASKER GEL DENGAN EKSTRAK DAUN MANGGA ARUMANIS (Mangifera Indica L.) SEBAGAI BAHAN AKTIF Helgiera, Tasyah; Br Ginting, Astriani Natalia; Bangar, Roy Indrianto
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1626

Exposure to ultraviolet (UV) radiation and environmental pollution can generate free radicals that contribute to skin damage and accelerate premature aging. One approach to protect the skin from these effects is the use of antioxidants derived from natural sources. Arumanis mango leaves (Mangifera indica L.) contain secondary metabolites such as flavonoids, tannins, and saponins which have potential antioxidant activity and can be utilized as active ingredients in cosmetic formulations. This study aimed to formulate a gel mask containing ethanol extract of arumanis mango leaves and to evaluate the physical quality of the preparation. The extract was obtained using the maceration method with 96% ethanol as the solvent. The gel mask was formulated into three different extract concentrations, namely 0%, 4%, and 6%. The physical evaluation included organoleptic test, homogeneity, pH, spreadability, and drying time tests. The results showed that the gel mask preparations exhibited good physical characteristics, with homogeneous appearance, pH values ranging from 5.16–6.26, spreadability of 5.5–6.8 cm, and drying time of 17–20 minutes. The variation in extract concentration affected the color of the preparation but did not significantly influence the overall physical stability of the gel. Therefore, ethanol extract of arumanis mango leaves can be formulated into a gel mask preparation that meets the physical quality requirements for skincare products.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL PADA BUAH BIT (Beta vulgaris L.) MENGGUNAKAN METODE DPPH (2,2-DIPHENYL-1-PICRYLHYDRAZIL) Nadeak , Dian Sry Rejeki; br ginting, Astriani Natalia; Harahan, Daimah Wirdatus Sanaun
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1637

Oxidative stress due to the accumulation of free radicals plays a role in the development of various degenerative diseases, so that natural antioxidant sources that can be scientifically evaluated are needed. Beetroot (Beta vulgaris L.) is known to contain bioactive compounds such as betalains, flavonoids, and polyphenols that have the potential as antioxidants. This study aims to evaluate the antioxidant activity of beetroot (Beta vulgaris L.) ethanol extract in vitro using the DPPH method. Extraction was carried out by maceration method using 96% ethanol. The antioxidant activity test was carried out using DPPH solution with absorbance measurement at a wavelength of 517 nm. The extract was tested at a concentration range of 10–100 µg/mL with three replications, while quercetin was used as a positive control. Antioxidant activity was expressed as the percentage of DPPH radical inhibition and the IC₅₀ value calculated using linear regression analysis. The results showed that the beetroot ethanol extract had an IC₅₀ value of 3.35 µg/mL, while quercetin had an IC₅₀ value of 2.76 µg/mL. The yield of the extract obtained was 20.29%. These results indicate that the beetroot ethanol extract has DPPH radical scavenging activity in the in vitro test system used.

ANALISIS BIAYA TERAPI ASPIRIN DAN CLOPIDOGREL PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT ROYAL PRIMA TAHUN 2022 – 2025 Nasution, Nursaima Putri; Harahap, Daimah Wirdatus Sanaun; Br Ginting, Astriani Natalia
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1647

Ischemic stroke is one of the leading causes of mortality and long-term disability, imposing a substantial economic burden due to high treatment and rehabilitation costs. Antiplatelet therapies such as aspirin and clopidogrel are commonly used for secondary prevention to reduce the risk of recurrent stroke; however, differences in treatment costs require evaluation to support efficient use of healthcare resources. This study aimed to analyze and compare the total cost and cost-effectiveness of aspirin and clopidogrel therapy in patients with ischemic stroke at Royal Prima General Hospital during the period 2022-2025. This study was an observational analytic study with a retrospective design using patients’ medical record data. The analysis was conducted from the hospital perspective by calculating direct medical costs, including drug costs, hospitalization, diagnostic examinations, and medical procedures. Pharmacoeconomic evaluation was performed using the Cost-Effectiveness Analysis (CEA) approach, with cost-effectiveness assessed through the calculation of the Cost-Effectiveness Ratio (CER) based on patients’ clinical outcomes. The results demonstrated differences in total treatment costs between aspirin and clopidogrel therapy, influenced by variations in cost components and patients’ clinical characteristics. In conclusion, cost-effectiveness analysis using CEA and CER can provide a scientific basis for selecting antiplatelet therapy that is rational and cost-efficient in the management of patients with ischemic stroke.

EFEKTIVITAS DAN BIAYA SEFALOSPORIN PADA PASIEN SIROSIS HEPATIS DENGAN RISIKO SPONTANEOUS BACTERIAL PERITONITIS DI RUMAH SAKIT ROYAL PRIMA PADA TAHUN 2022-2025 Dakhi, Grace Kristin Sonayania; Harahap, Daimah Wirdatus Sanaun; Br Ginting, Astriani Natalia
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1694

Hepatic cirrhosis is a chronic liver disease often accompanied by serious complications, one of which is spontaneous bacterial peritonitis (SBP), which plays a significant role in increasing morbidity and mortality. Third-generation cephalosporin antibiotics, such as cefotaxime and ceftriaxone, are widely used as first-line therapy in patients with hepatic cirrhosis at risk of SBP. However, the increasing incidence of bacterial resistance and the high cost of treatment require an evaluation of the clinical effectiveness and cost-efficiency of the therapy provided. This study aims to assess the effectiveness and cost of using cephalosporin antibiotics in patients with hepatic cirrhosis at risk of SBP at Royal Prima Hospital Medan during the period 2022–2025. This study uses a pharmacoeconomic approach in the form of Cost-Effectiveness Analysis (CEA) to assess the cost-effectiveness of cephalosporins based on the relationship between treatment costs and patient clinical outcomes. Cost-effectiveness is assessed through the calculation of the Cost-Effectiveness Ratio (CER). The results show that the characteristics of patients are predominantly male and in the adult to elderly age group. This finding is in line with the epidemiological characteristics of liver cirrhosis which is more common in men, especially due to long-term risk factors such as chronic liver disease and alcohol consumption. The study shows that the analysis of the Cost-Effectiveness Ratio (CER) and Cost-Effectiveness Analysis (CEA) values has a positive and significant effect on total medical costs, which indicates that increasing costs per unit of clinical outcomes will have a direct impact on increasing total treatment costs.

Title

Found 11 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 11 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 11 Documents
Search