<![CDATA[ABSTRACT Infectious diseases of the digestive system remain a major health problem, particularly in developing countries. Microorganisms such as bacteria, viruses, and parasites are the primary causes of gastrointestinal infections. This study aims to analyze the role of microorganisms in causing infectious diseases of the digestive system and the factors influencing their transmission. This study used a descriptive-analytic design with a cross-sectional approach. A total of 100 respondents were selected using purposive sampling. Data were collected through laboratory examinations and questionnaires, then analyzed descriptively and inferentially. The results showed that bacteria were the most common cause of digestive infections, followed by viruses and parasites. Hygiene and sanitation factors were significantly associated with infection incidence (p < 0.05). In conclusion, microorganisms play a significant role in gastrointestinal infections, and prevention can be achieved through improved hygiene and sanitation. Keywords: Microorganisms, Digestive Infection, Bacteria, Sanitation ABSTRAK Penyakit infeksi pada sistem pencernaan masih menjadi masalah kesehatan yang signifikan, terutama di negara berkembang. Mikroorganisme seperti bakteri, virus, dan parasit berperan penting dalam menyebabkan berbagai gangguan pencernaan, termasuk diare, gastritis, dan infeksi usus. Penelitian ini bertujuan untuk menganalisis peran mikroorganisme dalam menyebabkan penyakit infeksi pada sistem pencernaan. Penelitian ini menggunakan desain kuantitatif deskriptif dengan pendekatan cross-sectional. Sampel sebanyak 80 pasien dengan keluhan gangguan pencernaan diambil menggunakan teknik purposive sampling. Data dikumpulkan melalui pemeriksaan laboratorium dan rekam medis, kemudian dianalisis secara deskriptif dan bivariat. Hasil menunjukkan bahwa bakteri merupakan penyebab terbanyak (60%), diikuti virus (25%) dan parasit (15%). Mikroorganisme seperti Escherichia coli dan Salmonella menjadi penyebab dominan. Kesimpulannya, mikroorganisme memiliki peran utama dalam penyakit infeksi pencernaan, sehingga diperlukan upaya pencegahan melalui sanitasi dan higiene yang baik. Kata Kunci: Mikroorganisme, Infeksi Pencernaan, Bakteri, Virus, Parasit]]>
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