<![CDATA[Myopia is a refractive disorder whose prevalence continues to increase globally and represents a significant eye health problem among adolescents and young adults. In addition to genetic and environmental factors, metabolic factors are thought to play a role in the development and severity of myopia. This study aims to analyze the relationship between Body Mass Index (BMI) and leptin levels and the degree of myopia in students at the Faculty of Medicine, University of North Sumatra. This study employed an observational analytical design with a cross-sectional approach involving 50 students with myopia. The data collected included BMI, visual acuity, degree of myopia, and serum leptin levels, and were analyzed using Chi-square, one-way ANOVA, and Kruskal–Wallis tests based on data distribution. The results showed a significant relationship between BMI and leptin levels (p < 0.001), with leptin levels increasing as BMI rose, particularly in the obese group. BMI was also significantly associated with the degree of myopia (p < 0.001), with moderate to severe myopia being more common in obese subjects. Additionally, leptin levels were significantly associated with myopia severity (p < 0.001), with higher levels observed in moderate and severe myopia compared to mild cases. The study concludes that BMI and leptin levels are associated with the degree of myopia in college students, indicating the role of metabolic factors in myopia progression. These findings may serve as a basis for developing prevention and management strategies through a multidisciplinary approach that includes nutritional and metabolic aspects.]]>
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