<![CDATA[Background: This study was motivated by the increasing use of herbal medicines in the community, which is often not accompanied by adequate toxicological safety data. Combretum indicum (L.) DeFilipps is a widely used traditional medicinal plant, but scientific information regarding the acute toxicity of its ethanol extract is still limited. Objective: To evaluate the acute toxicity profile of the ethanol extract of C. indicum as a basis for determining its safety. Methods: The study was conducted experimentally using a fixed-dose method in accordance with OECD guidelines (Kpemissi et al., 2020). The test animals were female white Wistar rats given C. indicum ethanol extract orally at doses of 50, 100, 300, and 2000 mg/kgBW. Parameters observed included general condition, clinical toxic symptoms, weight changes, and mortality over 14 days of observation. Results: The results showed that all test animals remained active and did not display toxic symptoms or mortality at all doses tested. The rats' body weight showed a normal increase with no significant differences between groups. These findings indicate that the ethanol extract of C. indicum has a low level of acute toxicity, with an estimated LD50 of more than 2000 mg/kgBW. Conclusion: The ethanol extract of C. indicum is relatively safe upon acute exposure and has the potential to be developed as a herbal preparation, although further toxicity testing is still needed to ensure long-term safety.]]>
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