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LPPM Universitas Sari Mulia Gedung D Lantai 1 JL. Pramuka No. 02 Banjarmasin Kelurahan Pemurus Luar Kecamatan Banjarmasin Timur Kota Banjarmasin Kalimantan Selatan Indonesia
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INDONESIA
Journal of Pharmaceutical Care and Sciences
Published by Universitas Sari Mulia
ISSN : -     EISSN : 28284828     DOI : https://doi.org/10.33859/jpcs.
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Journal of Pharmaceutical Care and Sciences published by the LPPM Sari Mulia UniversityPharmacy department of Sari Mulia University offers a forum for publishing the original research related to pharmaceutical science and clinical research. our focus and scope are Pharmaceutical Technology, Pharmacology & Toxicology, Drug Delivery Development, Pharmacokinetic & Biopharmaceutics, Pharmacoeconomy, Pharmacoepidemiology, Pharmacovigilance, Clinical Pharmacy, Community Pharmacy, Chemical Pharmacy, and Chemical Analysis.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 162 Documents
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ANALISIS KADAR SULFAT SO42- PADA AIR MINUM YANG MENGANDUNG TAWAS DENGAN MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-Vis Darni Darni Darni; Rahmadani Rahmadani; Tuti Alawiyah
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

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Abstract

ABSTRACT Background Alum is an aluminum sulfate compound consisting of sulfate double salts which has metal ions. Has the chemical formula [Al2(SO4)3.18H2O]. The maximum level of sulfate that is allowed to be contained in drinking water is regulated by the Republic of Indonesia Regulation No.492/Menkes/Per/IV/2010 of 250 mg/l. Objective To find out sulfate levels in drinking water samples consumed by Lok Buntar Village community. Method The study used an Analytical Observational Prospective Cohort Design. The population of the Lok Buntar Village research population is alum use as a water purifier that is used as drinking water. The research sample is boiled drinking water containing sulfate (alum) in Lok Buntar Village. Taken by purposive sampling. Data analysis using linear regression to determine levels. Results SO42- sulfate levels at volume of 150 L obtained 53.184 mg/l, at a volume of 100 L that is 42.162 mg/l, at a volume of 50 L obtained levels of 40.266 mg/. Ha ≠ 0 there are SO42- levels in drinking water at the sampling point at volumes of 150 L, 100 L and 50 L. Conclusion: The presence of SO42- sulfate levels at the sampling point at a volume of 150 L is 53.184 mg/l, 100 L is 42.162 mg/l and 50 L is 40.266 mg/l. Keywords Drinking Water, SO42- Sulfate Levels, UV-Vis Spectrophotometry.
Analisis Kadar Surfaktan Anionik Pada Air Sungai Barito Menggunakan Metode Spektrofotometri Visible Nurul Fajriah; Tuti Alawiyah; Ikna Urwatul Wusko
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

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Abstract

ABSTRACT BACKGROUND: Water is one of the resources that contains the main needs including humans, animals and plants. Indonesia is a country that has a lot of air resources and is known as a maritime country consisting of thousands of islands. Indonesia also has more than 500 rivers. One of them is the Barito River located in Ulu Benteng Village RT.11 Barito Kuala Regency is still used by the community for daily needs. One of them is used for clothing and drinking water sources. OBJECTIVE: To determine and compare the levels of anionic surfactants in the Barito river with different time intervals, namely the 1st, 4th and 7th days. METHODS: This research uses descriptive research with group design. The population and sample used were all of the Barito River water with inclusion and exclusion criteria using the Visible Spectrophotometer method. RESULTS: Significant value of the results of calculations using SPSS of 0.593 with the results of the value of the relationship coefficient (r) 0.997 and the results of the first day level of 4 mg/L, day 4 of 2 mg/L and day 7 of 2, 8 mg/L which determines levels exceeding the normal threshold that has been determined by Government Regulation No. 82 of 2001 which is 0.2 mg/L. CONCLUSION: Anionic surfactant content in the Barito River water has a value that exceeds the threshold of Government Regulation Number 82 Year 2001, namely on day 1 of 4 mg/L, day 4 of 2 mg/L and day 7 of 2,8 mg/L. The significance value is 0.593 which means that there is no time difference and the hypothesis is rejected. Keywords: Visible Spectrophotometer, Barito River, Anionic Surfactant
Studi Farmakovigilans Efek Samping Multivitamin Dimasyarakat Palangka Raya Khoirul Nur Pratiwi; Iwan Yuwindry; Onieqie Ayu Dhea Manto
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

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Abstract

ABSTRACT Background: Multivitamins play an important role in the body to regulate activities in the body. One of the effects of taking excess multivitamins can cause poisoning or other adverse symptoms called hypervitaminosis. Objective: To find out what advers drug reactions occurred as a result and how many incidents of multivitamin use in children aged 5-11 years. Methods: This type of research uses descriptive observational with a cross sectional design. The research was conducted using the Naranjo algorithm, which distributes questionnaires online in the form of google from to social media and after being filled in by respondents, it will be sorted according to the inclusion criteria. Results: This study showed 36 samples that met the inclusion criteria, where demographic characteristics for the female gender were more dominant by 55.556%. Based on the age of respondents as much as 25% who consume multivitamins aged 11 years, and multivitamin type profiles that are widely used are curcuma plus 27,778%. The results of the Advers Drug Reaction incident were 5 respondents to Curcuma Plus, Imboost which caused abdominal pain by 2 respondents, and Muveron which caused nausea by 1 respondent. Based on the assessment with naranjo scores for respondents who experienced Advers Drug Reaction obtained 7 respondents in the Possible category and 1 respondent in the Probable category. one of the factors that influence such as how to consume it is not right. Conclusion: This study can conclude a causal description of the incidence of Advers Drug Reaction in respondents using multivitamins, 7 respondents in the Possible category and 1 respondent in the Probable category. Keywords: Advers Drug Reaction, Multivitamins, Naranjo
SKRINING FITOKIMIA SERTA UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA KETEPENG CINA (Senna alata (L.) Roxb.) DENGAN METODE DPPH EKA RIA SAFITRI; Rohama Rohama; Putri Vidiasari D.
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

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Abstract

Indonesia has a variety of plants that have potential as herbal medicines which are still unknown to many people, one of them is Chinese ketepeng flowers. Empirically in South Barito District, Central Kalimantan, Chinese ketepeng plants have been used for various diseases. Based on this the researcher intend to conduct further research on antioxidant activity in the Chinese ketepeng flowers. To determine secondary metabolite compounds and antioxidant activity contained in Chinese Ketepeng flower extract. This type of research is experimental research, with Posttest Only Control Group Design. Extraction is done by maceration method. Phytochemical screening is done by color reagents and TLC. Test antioxidant activity with the DPPH method. 350 grams of Chinese ketepeng flower extraction with 9 L of 96% ethanol obtained thick extract of 35.34 gram. The results of phytochemical screening with color reagents and TLC extract of positive Chinese ketepeng flowers contain flavonoids, phenolic compounds, saponins and tannins. Antioxidant activity test results obtained by 185.037 ppm. Chinese ketepeng extract contains secondary metabolites of flavonoids, phenolic, saponin and tannin compounds and obtained antioxidant activity of 185,037 ppm. Keywords:Antioxidants, Senna alata (L.) Roxb.flower, Phytochemicals
Hubungan Tingkat Pengetahuan Masyarkat Terhadap Penggunaan Antibiotik Di Kelurahan Alalak Utara Shofia Rahmi; Darini Kurniawati; Nurul Hidayah
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

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Abstract

Background: Antibiotics are drugs that used to treat infections. Irrational use of antibiotics can increase the incidence of bacterial resistance. The proper use of antibiotics is influenced by several factors, one of the factors is knowledge. Objective: Analyze the relationship between the level of society knowledge and rational use of antibiotics in the North Alalak Village. Methods: This research used observational analytics design (non-experimental) and cross – sectional study design. The population are adult communities with ages around 20-60 years in North Alalak Village. The researcher take 45 people as sample by using purposive sampling. Measure tools or instrument that the researcher used is validated questionnaire. Data was analyzed by using Spearman Rho with 95% level of confidence. Results: The results of the respondents knowledge level in good categories were 4 people (8.9%), quite were 25 people (55.6%) and less were 16 people (35.6%). The results of using antibiotics rationally by respondents were 3 people (6.7%) and irrationally by 42 people (93.3%). The prevalence ratio (PR) value obtained was 20.83 and the Spearman rho test results obtained were a significance value of 0.014 (<0.05), a correlation coefficient of 0.364 and a positive correlation direction. There is a correlation between the level of knowledge and the use of antibiotics in the society in North Alalak village. Conclusion: Knowledge about antibiotics is related to rational antibiotic use. People needs to add more information about rational use of antibiotics with counseling guidance, seminars and other information.
Uji Farmakognostik dan Identidikasi Senyawa Pada Beberapa Tingkatan Fraksi Ekstrak Etanol Daun Lengkuas (Alpinia Galanga) Yanti Saubari; Kunti Nastiti; Mambang Mambang
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.6 KB) | DOI: 10.33859/jpcs.v1i1.27

Abstract

ABSTRACT Background:Galangal Leaves (Alpinia Galanga) is a plant that grows in Indonesia. This plant is used as a cleaning wound after childbirth, bathing water for rheumatism sufferers, and as stimulation. Objective: To find out about the results of Pharmacognostic Tests and Identification of Compounds at Several Levels of The Ethanol Extract Fractions of Galangal Leaves (Alpinia Galanga) Method: extraction process using maceration method with 70% ethanol solvent was carried out for 3 x 24 hours, evaporated with rotary vacuum evaporator until thick extract was then fractionated with different solvents and detected by secondary metabolites using color test and KLT method Results: Macroscopic tests included a slippery green color with a length of 40cm, width 8cm, flat edge, pointed tip, blunt leaf base, and crossing. Microscopic test is the presence of epidermis, parenchyma, and stomata. Results Physico-chemical parameters of drying shrinkage were 0.23%, extracts of solvents with certain solvents were water-soluble and ethanol-soluble were 0.405% and 0.395%. Phytochemical screening results of the compounds obtained in the n-hrxane fraction, ethyl acetate fraction, and methanol fraction are steroids, tannins, phenolics, terpanoids, alkaloids, saponins, and flavanoids. KLT results for the n-hexane fraction with a mobile phase of methanol: ammonium (5: 0.25) with a spray of red brick (alkaloid). Conclusion: pharmacognostic testing meets the requirements and extracts of Galangal Leaves (Alpinia Galanga)
Analisis Kadar Tanin Ekstrak Etanol Kulit Batang Kemiri (Aleurites moluccana (L.) Willd) dengan Metode Titrimetri Sofiya Maulida; Ali Rakhman Hakim; M. Sobirin Mohtar
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

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Abstract

Introduction: Plants have a great potential to be used as traditional medicine, so it is necessary to standardize realated compounds responsible for pharmacological activities or secondary metabolite compounds of a plant. One of medicinal plants is candlenut, this is plant has many uses in almost all parts of the plant. Candlenut stem bark has been used as traditional medicine by the community in Muara Langon village, Paser district, East Kalimantan to treat hypercholesterolemia. Objective: To know the candlenut stem bark ethanol extract containing flavonoid, saponin, tannin compounds and knowing the levels of tannin compounds contained in the sample. Methods: Extraction was carried out by maceration method. Qualitative analysis was carried out by phytochemical screening tests for flavonoid, saponin and tannin compounds by the tube method. Quantitative analysis was carried out by determining the levels of tannin compounds using the titrimetry method by permanganometric titration. Results: The extraction of 500 grams candlenut stem bark and 4 liters ethanol 70% sovent obtained was the extract rate od 4,022%. The results of the qualitative analysis by phytochemical sreening test showed that the candlenut stem bark ethanol extract is positively contained flavonoid, saponin and tanin compounds. The result of quantitative analysis with titrimetry method obtained levels of tannin compounds in the candlenut stem bark ethanol extract is 5,40598 %. Conclusion: The candlenut stem bark ethanol extract contained flavonoid, saponin and tanin compounds and tannin compound levels is 5,40598 %. Keywords: Candlenut stem bark, Tannin levels, Titrimetry.
UJI DISOLUSI TERBANDING ANTARA SEDIAAN TABLET RAMIPRIL GENERIK DAN BERMEREK Noorjannah Noorjannah; Noval Noval
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

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Abstract

Introduction: Ramipril is a medicine that used as hypertension medication, kidney failure. Ramipril is one of the medicines that needs to be comparable dissolution tested which has been regulated in the Regulation of the Drug and Food Control Agency Head Number HK.03.1.23.12.11.12017 year 2011 regarding Obligatory Comparable Dissolution Test. The comparable dissolution test used to make sure the equivalence and characteristics of a medicinal product of 2 samples or more. Purpose: To find out the physique quality and the profile difference of comparable dissolution speed between generic and branded ramipril. Methods: This research was conducted using the Cross Sectional design with correlation learning between risk factor and effect with conducting an approach. The risk factor is the generic and branded ramipril. Meanwhile, the effect factor is the effect that caused by the result of the comparable dissolution test. The data were analyzed using One Way Anova test. Results: In the research, the result of the conducted physique quality test on four samples is already qualified. In the dissolution test, sample 1 (generic) compared with the branded samples which are sample 2, sample 3, and sample 4 that have different dissolution speed. The lowest dissolution speed is in the generic sample which is sample 1 and the highest dissolution speed is in the branded sample which is sample 4. Conclusion: The result of the physique quality test is already qualified, meanwhile the result of the dissolution test is that there is a profile difference of dissolution speed between generic and branded samples. Keyword: Generic and Branded Ramipril, Comparable Dissolution
Efektivitas Terapi Antihipertensi Pada Kasus Krisis Hipertensi di Instalasi Gawat Darurat RSUD Ulin Banjarmasin Evita Peron Yoewono; Rina Saputri; Rifa’atul Mahmudah
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

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Abstract

ABSTRACT Background: Hypertension crisis is a case of disease that often occurs, if not handled properly will cause comlication and death. This study was conducted to determine effective therapies in dealing with hypertensive crises so as to minimize the occurrence of complication and death in patients experiencing hypertensive crises Method: The research method is a prospective cohort. Data analysis using Pair T-Test and ANOVA, analytic analysis with evidence based medecine principles. Consists of 11 urgent hypertension samples and 9 emergency hypertension samples. Results: The results of the study for the case of hypertension urgency there are 6 therapeutic groups including furosemide, nicardipine, amlodipine, candesartan + amlodipine, clonidine and furosemide + nicardipine, but the therapy used is not in accordance with the guidelines but there are 2 groups of therapies that can reduce blood pressure including furosemide + nicardipine and clonidine, while for the case of emergence hypertension, there are 5 groups of therapies including nicardipine, amlodipine + nicardipine, furosemide, furosemide + candesartan + amlodipine and furosemide + candesartan + amlodipine + clonidine, the result is that nicardipine is a therapy that is in accordance with the guideline and the therapy is in accordance with the guideline and is in accordance with the guideline therapeutic target in lowering blood pressure. Conclusion: The use therapy is not in accordance with the guidelines for patients with hypertensive urgency cases, but is able to lower the patient’s blood pressure, whereas for patients with hypertensive emergencies the effective therapy is nicardipine. Keywords: Blood Pressure, Effectiveness, Hypertensive Crisis, Urgency Hypertension, Emergency Hypertension.
Uji Aktivitas Antibakteri Ekstrak Etanol Kulit Kayu Laban (Vitex pubescens Vahl) terhadap bakteri Escherichia coli Talitha Cresentia Rahma; Dyan Fitri Nugraha
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.297 KB) | DOI: 10.33859/jpcs.v1i1.36

Abstract

Background: In the world, 800.000 children die every year due to diarrheal diseases. Chronic diarrhea is usually caused by a bacterial infection, one of which is E. coli. Empirically, Dayaknese in Sampit, Central Kalimantan consuming Laban bark to treat diarrhea and dysentery. Through this research, people get scientific information about Laban wood as an alternative herbal medicine for treating diarrhea. Objective: To find out whether Laban bark can inhibit Escherichia coli bacteria and to determine the minimum inhibitory concentration in Laban bark extract that can inhibit Escherichia coli bacteria. Methods: This type of research used true experimental design with research post test only control group design. The research subjects were Escherichia coli cultured on Muller Hinton Agar (MHA) media and Laban bark extract with 3 different concentrations using the disc diffusion method. This study had 2 control groups and 3 treatment groups, DMSO as negative control, ciprofloxacin as positive control and ethanol extract of Laban bark with concentrations of 25%, 50%, and 75%. Inhibition zone diameter results were analyzed quantitatively in 3 replications. Results: The results showed that the concentrations of 25%, 50% and 75% of the extract had bacterial inhibition, in the very strong antibacterial category. Conclusion: The ethanol extract of Laban bark can inhibit the growth of Escherichia coli with an minimun inhibitory concentration 25%, which is in the very strong inhibition category. Keywords: Disc diffusion, Escherichia coli, Laban bark (Vitex pubescens Vahl)

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