AMELIORATIVE EFFECTS OF HYDROALCOHOLIC OCIMUM BASILICUM LEAF EXTRACT ON BIOCHEMICAL AND HISTOLOGICAL ALTERATIONS IN CISPLATIN-INDUCED CARDIOTOXICITY IN MALE WISTAR RATS

Novitasari Tarigan (Universitas Prima Indonesia)
Feby Dianda (Universitas Prima Indonesia)
I. Nyoman Ehrich Lister (Universitas Prima Indonesia)
Edy Fachrial (Universitas Prima Indonesia)

International Archives of Medical Sciences and Public Health
Vol. 6 No. 2 (2025): International Archives of Medical Sciences and Public Health

Cardiotoxicity is a common side effect of cisplatin (CIS) chemotherapy, often accompanied by gastrointestinal, renal, and hematological toxicities. This study investigated cardioprotective potential of hydroalcoholic basil leaf extract against CIS-induced toxicity in rats, evaluated through Troponin-T, high-sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), malondialdehyde (MDA) levels, and cardiac histopathology. A quasi-experimental design was employed with eight groups of rats (n = 6 per group): normal, negative control, positive control (vitamin C), and treatment groups receiving basil extract (400 and 800 mg/kg body weight). CIS administration significantly elevated Troponin-T, Hs-CRP, and MDA levels while reducing SOD activity. Treatment with basil extract, particularly at 800 mg/kg, markedly attenuated these changes, restoring biochemical markers toward normal values. Histopathological analysis further confirmed the cardioprotective effect. In conclusion, basil leaf extract demonstrates promising potential as a cardioprotective agent against CIS-induced cardiotoxicity.