Hydrogen: Jurnal Kependidikan Kimia
Vol. 14 No. 2 (2026): April 2026

In Vitro Evaluation of the Anti-Diabetic Potential of Oxovanadium(IV) Complex with Terpyridine Ligand

Nisa, Fakhrotun (Unknown)
Onggo, Djulia (Unknown)



Article Info

Publish Date
30 Apr 2026

Abstract

An oxovanadium(IV) complex with 2,2′:6′,2″-terpyridine ligand, [VO(terpy)]SO₄, was synthesized and characterized to evaluate its anti-diabetic potential. The complex was synthesized via a direct reaction between VOSO₄ as the metal source and terpyridine ligand in solution and confirmed through conductometric and mass spectrometric analyses. Conductivity measurements indicated that the complex behaves as a 2:2 electrolyte in aqueous solution, dissociating into [VO(terpy)]²⁺ and SO₄²⁻ ions. Mass spectrometry revealed a peak at m/z 150.0098 corresponding to the cationic species. The anti-diabetic activity was evaluated through in vivo studies using alloxan-induced diabetic rats, demonstrating a significant reduction in fasting blood glucose levels. These findings suggest that the oxovanadium(IV)–terpyridine complex is a candidate for further development as an anti-diabetic agent.

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Journal Info

Abbrev

hydrogen

Publisher

Subject

Chemistry Education

Description

Hydrogen: The Chemistry Education Journal published by the Chemistry Education Study Program which contains articles raised from the results of conceptual research and studies in chemistry and chemistry education including education and learning, device development, media and learning ...