SYNTAX Score II as a Predictor of One-Year Major Adverse Cardiovascular Events in Patients with Chronic Coronary Syndrome and Type 2 Diabetes Mellitus Undergoing Percutaneous Coronary Intervention

Elsa Tamara Saragih (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara and Adam Malik Hospital, Medan, 20155, Indonesia)
Harris Hasan (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara and Adam Malik Hospital, Medan, 20155, Indonesia)
Abdul Halim Raynaldo (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara and Adam Malik Hospital, Medan, 20155, Indonesia)
Cut Aryfa Andra (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara and Adam Malik Hospital, Medan, 20155, Indonesia)
Teuku Bob Haykal (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara and Adam Malik Hospital, Medan, 20155, Indonesia)
Kamal Kharazzi Ilyas (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara and Adam Malik Hospital, Medan, 20155, Indonesia)

Sumatera Medical Journal
Vol. 9 No. 2 (2026): Sumatera Medical Journal (SUMEJ)

Background: The severity of coronary atherosclerotic lesions is an important determinant of cardiovascular events in patients with CAD. The SS-II (SYNTAX-II) score, which integrates anatomical characteristics with clinical variables, provides improved prognostic value compared with anatomical scoring alone. Objective: To determine whether the SS-II predicts one-year MACE in CCS patients with T2DM who undergo PCI. Methods: This observational analytic study employed a retrospective cohort design including patients treated from June 2023 to August 2024. A total of 128 CCS patients with T2DM who underwent PCI were enrolled. Bivariate and multivariate analyses were performed to examine the association between the SS-II and MACE. One-year MACE-free survival was analyzed using Kaplan–Meier curves.  Results: MACE occurred more frequently among patients with high SS-II scores (22 [34.4%], P < 0.001). Mortality and acute heart failure were both significantly associated with the SS-II (P = 0.042 and P = 0.03, respectively). Patients with high scores had significantly lower one-year MACE-free survival. Conclusion: The SS-II is a valuable predictor of one-year MACE in CCS patients with T2DM undergoing PCI.