<![CDATA[The purpose of this study was to determine the gastroprotective activity of ethanol extract of bau langit stem bark in the stomachs of paracetamol-induced rats. This research uses experimental method. Data analysis used a completely randomized design (CRD) with 5 treatments and 5 replicates. All treatments except normal control (K0) in esophageal intubation of paracetamol at a dose of 1350 mg/kg BB. Negative control (K-) is given aqueous for 14 days. P1, P2 and P3 treatments were given Cyathocalyx sumatranus extract of 150 mg/kg BB, 300 mg/kg BB and 600 mg/kg BB respectively. The treatment was given for 14 days and on the 7th day paracetamol was induced. Samples of gastric tissue were made histopathological preparations with paraffin method and hematoxylin-eosin (HE) staining. The variables observed include desquamation, erosion and ulceration of the gastric mucosa. The results showed that the gastric mucosa treated with K0, K-, P1 and P2 was desquamated. Erosion occurs in the treatment of K-. Ulceration was not found in all treatments. Paracetamol at a dose of 1350 mg/kgBB can induce erosion. The conclusion of this study is that the administration of C. sumatranus extract at doses of 300 mg/kgBB and 600 mg/kg BB is able to reduce gastric mucosal erosion due to paracetamol induction, while the dose of 150 mg/kg BB of C. sumatranus extract has not been able to prevent gastric mucosal damage.]]>
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