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Jurnal Bioleuser
Published by Universitas Syiah Kuala
ISSN : 25976753     EISSN : 25976753     DOI : https://doi.org/10.24815/jurnalbioleuser.v[X]i[X].
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Focus The journal focuses on high-quality research that advances the understanding of biological systems, particularly those relevant to tropical and regional contexts in Indonesia and Southeast Asia. Bioleuser Journal welcomes contributions from researchers, academics, and practitioners across all subdisciplines of biology. Scope Bioleuser Journal publishes research articles, review articles, and short communications in the following areas: Botany Zoology Microbiology Genetics Ecology Physiology Biochemistry Molecular Biology Conservation Biology Bioinformatics The journal encourages interdisciplinary research and studies that integrate multiple biological fields to advance scientific understanding of living systems, particularly those relevant to tropical environments and biodiversity conservation.
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Articles 36 Documents
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Studi Literatur Michelia champaca L. dan Potensinya Sebagai Antikanker dan Antimikroba Widya Syahfitri; Zulia Ananda; Febry Rahmadhani Hasibuan
Jurnal Bioleuser Vol. 10 No. 1: April 2026
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v10i1.906

Abstract

Michelia champaca L. is a tropical plant widely utilized in Southeast Asian traditional medicine and recognized for its rich diversity of secondary metabolites. Recent phytochemical investigations have demonstrated that this species contains a broad spectrum of bioactive compounds, including flavonoid glycosides, aporphine alkaloids, phenolic compounds, terpenoids, and sesquiterpene lactones, all of which exhibit significant pharmacological potential. This review aims to systematically synthesize current scientific evidence on the phytochemistry and bioactivities of M. champaca, encompassing the isolation of bioactive constituents, characterization of metabolite profiles, and evaluation of antioxidant, antimicrobial, analgesic, cytotoxic, and anticancer activities. Available findings indicate that the leaves of M. champaca contain four newly identified flavonol diglycosides, along with numerous other flavonoid glycosides, which exhibit strong antioxidant activity as demonstrated by both chemical assays and intracellular reactive oxygen species (ROS) suppression. Aporphine alkaloids, particularly liriodenine isolated from the branches, have shown significant antiproliferative effects against A549 lung carcinoma and MDA-MB-231 breast cancer cell lines. Furthermore, antimicrobial activity is predominantly associated with the ethyl acetate and n-butanol fractions, which effectively inhibit the growth of Gram-positive and Gram-negative bacteria as well as pathogenic fungi. In addition, methanolic leaf extracts demonstrate notable analgesic and cytotoxic activities. Overall, this review underscores M. champaca as a promising source of bioactive metabolites with considerable potential for phytopharmaceutical development, particularly as natural antioxidants, antimicrobial agents, and anticancer therapeutics. The compiled evidence provides a robust scientific basis for future investigations into molecular mechanisms and the development of plant-based therapeutic formulations.
Inventarisasi Jenis-Jenis Ikan di Kawasan Ekowisata Hutan Bakau Kuala Langsa, Kota Langsa, Aceh Hijratul Abdi; Cut Nanda Defira; Zuriana Siregar; Irvianty Irvianty; Suwarno Suwarno; Aida Fithri
Jurnal Bioleuser Vol. 9 No. 3: Desember 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v9i3.1275

Abstract

The Kuala Langsa Mangrove Forest Area is a mangrove ecosystem in Langsa City that has been designated as an ecotourism area. The conversion of the Kuala Langsa mangrove forest area into an ecotourism area is suspected to cause changes in fish habitat, thus affecting fish populations. Research on fish species inventory in the mangrove forest ecotourism area is very relevant to understand the negative impacts of ecotourism on fish and the surrounding environment. An inventory of fish species in the Kuala Langsa Mangrove Forest Ecotourism Area was conducted from February to August 2024. This study aims to determine the species of fish found in the Kuala Langsa Mangrove Forest Ecotourism Area. The method used was an exploratory survey, by exploring the Kuala Langsa Mangrove Forest Ecotourism Area. The search started from the observation tower area to the river mouth. Sampling points were adjusted to environmental conditions, namely depth and habitat conditions. Sample collection was carried out using gill nets and nets, with 9 gill net installation points and 18 net throwing points. Sampling was carried out three times at each location. The research results obtained 90 individuals, consisting of 16 families and 18 species. The species with the largest number of individuals was found in the Gerres erythrourus (kapas) species with 12 individuals, followed by the Hyporhamphus balinensis (julung) species with 11 individuals, and the Sillago sihama (rejung) species with 9 individuals. The least number of species was found in the Caranx ignobilis (rambeu), Platycephalus indicus (baji-baji) and Lactoria cornuta (helicopter) species with one individual each.
Kontaminasi Logam Berat pada Tanaman Pangan & Implikasinya Terhadap Keamanan Pangan di Indonesia Salmina Ulfa; Nidaul Ulfa; Aura Angelica Kirana; Firdus Firdus; Muhammad Nasir; Alia Rizki
Jurnal Bioleuser Vol. 10 No. 1: April 2026
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v10i1.1401

Abstract

Heavy metal contamination in agricultural soils has become a serious threat to crop productivity, food safety, and human health. Sources of contamination include both geogenic processes and anthropogenic activities. These human activities range from the use of fertilizers and pesticides to the disposal of industrial waste and irrigation with contaminated water. These various factors contribute to increased levels of cadmium (Cd), lead (Pb), and arsenic (As) in soil and food crops. The bioavailability of these metals is largely controlled by soil properties, including pH and organic matter content, as well as rhizosphere processes that determine metal uptake, translocation, and accumulation in edible plant tissues. At the molecular level, the uptake and transport of heavy metals involve specific transporters, such as OsNramp5 for Cd and Lsi1/Lsi2 for As, which function together with chelation mechanisms, vacuolar detoxification, and the regulation of defense-related genes and stress hormones. Recent studies highlight the importance of multi-metal interactions, including antagonistic relationships between zinc (Zn) and cadmium (Cd) and competition between arsenic (As) and silicon (Si), as well as the role of soil and rhizosphere microbiomes in mobilizing or immobilizing heavy metals. The accumulation of heavy metals in food crops has been shown to increase both carcinogenic and non-carcinogenic health risks for consumers, particularly in agricultural areas located near industrial zones or those using wastewater for irrigation. Therefore, understanding the sources, bioavailability, and mechanisms of heavy metal accumulation—together with molecular and microbiological approaches—is essential for developing effective mitigation strategies and breeding safer food crops.
Analisis Komparatif Kadar Flavonoid Centella asiatica Berdasarkan Variasi Pelarut Ekstraksi: Tinjauan Sistematis Fitri Elizabrth Hasibuan
Jurnal Bioleuser Vol. 10 No. 1: April 2026
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v10i1.1427

Abstract

Centella asiatica (L.) Urb. is a medicinal plant rich in bioactive compounds, particularly flavonoids, which contribute significantly to its antioxidant activity. The extraction efficiency of flavonoids is strongly influenced by the type of solvent used during the extraction process. This study aimed to evaluate the effect of extraction solvent variation on the total flavonoid content (TFC) of C. asiatica (L.) Urb through a systematic review approach. A comprehensive literature search was conducted across six electronic databases covering publications from 2015 to 2025. Study selection was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of six eligible studies met the inclusion criteria and were included in the review, yielding 18 extraction datasets. The extracted information included solvent type, extraction method, analytical technique, and TFC expressed as mg quercetin equivalent per gram (mg QE/g). The results demonstrated that the TFC of C. asiatica (L.) Urb ranged from 1.89 to 48.43 mg QE/g. Ethyl acetate produced the highest TFC (48.43 mg QE/g), followed by ethanol (26.66–31.63 mg QE/g), whereas water yielded comparatively lower TFC values (7.26–9.33 mg QE/g). These findings indicate that semi-polar solvents are more effective than highly polar solvents in extracting flavonoids from C. asiatica (L.) Urb. In addition to solvent type, solvent concentration and analytical methods were identified as contributing factors to the variability of TFC reported among studies. Therefore, the selection of an appropriate extraction solvent is crucial for maximizing the recovery of flavonoids from C. asiatica (L.) Urb.
Toksisitas Aktinobakteri ATS-7 Asal Tanah Stasiun Penelitian Soraya Kawasan Ekosistem Leuser Berdasarkan Waktu dan Suhu Inkubasi Dhea Amanda Adryan; Lenni Fitri; Fauziah Fauziah
Jurnal Bioleuser Vol. 9 No. 3: Desember 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v9i3.1430

Abstract

Actinobacteria are prokaryotic microorganisms that have a morphological form resembling filamentous fungi, and are generally found in soil and have many beneficial potentials. This study aims to determine the effect of the toxicity test of actinobacteria ATS-7 from the soil of the Soraya Research Station based on incubation time and temperature. Toxicity testing was carried out using the Brine Shrimp Lethality Test (BSLT) method to obtain the LC₅₀ value. The toxicity test was carried out by calculating the number of dead Artemia salina larvae. The results of the toxicity test showed that the ATS-7 isolate at a temperature of 32ºC which was shaken for 5 days with an LC₅₀ value of 77.49 ppm, 10 days with an LC₅₀ value of 62.88 ppm, 15 days with an LC₅₀ value of 53.70 ppm. This temperature has very high toxicity activity, and has an LC₅₀ value of <100 ppm, meaning that the incubation time at 32ºC greatly affects the toxicity test and is very toxic.
Targeting Growth Factor Receptors in Cancer Insights from Molecular Docking Studies: A Literature Review Imelda Maelani; Widya Syahfitri; Fitri Elizabrth Hasibuan2 Hasibuan
Jurnal Bioleuser Vol. 9 No. 3: Desember 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v9i3.1431

Abstract

Growth factor receptors (GFRs) are essential transmembrane proteins that regulate key cellular processes such as proliferation, differentiation, migration, and survival. Their aberrant activation is strongly linked to cancer initiation, progression, and therapeutic resistance. Although several studies have explored GFR inhibition experimentally, the integration of in silico approaches remains underdeveloped. This review critically examines recent applications of molecular docking in identifying and characterizing inhibitors targeting major GFR families, including EGFRs, IGFRs, VEGFRs, TGF-βRs, FGFRs, and PDGFRs. A systematic literature search was conducted across major databases to summarize ligand–receptor interactions and binding mechanisms reported between 2004 and 2024. The analysis reveals that molecular docking effectively predicts ligand affinity and receptor selectivity, enabling the identification of natural and synthetic compounds with potent inhibitory potential. Moreover, patterns across docking studies indicate distinct binding preferences among receptor subtypes, providing valuable insights for structure-based drug design. Despite its predictive power, limitations such as receptor rigidity and lack of biological context highlight the need for integration with dynamic simulations and experimental validation. Overall, this review underscores the promise of docking-based screening as a strategic tool for accelerating the discovery of selective and safer anticancer agents targeting GFRs.
Studi Etnobotani Kapur Barus (Dryobalanops aromatica Gaertn.) pada Masyarakat Lokal di Kawasan Tahura Lae Kombih, Kecamatan Penanggalan, Subulussalam (Isolation and Analysis of Proteolytic Activity of Local Actinomycetes from Aceh, Indonesia) Ramadani Sinaga; Essy Harnelly; Saida Rasnovi; Zulia Ananda
Jurnal Bioleuser Vol. 9 No. 2: Agustus 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v9i2.1432

Abstract

Lae Kombih Botanical Forest Park is a nature conservation area with the aim of collecting natural and artificial plants and animals that can be utilised for research, science, tourism, and cultural preservation. This study aims to determine the traditional use of camphor (Dryobalanops aromatica Gaertn.) by the local community of Penanggalan District, Subulussalam City. This research used a descriptive survey method through a qualitative-quantitative approach. The results showed five main forms of camphor utilisation by the community, namely as building materials, medicines, natural fragrances for preserving corpses, perfume-making mixtures and food ingredients as building materials, the highest use was found in Sikelang Village (33.33%), followed by Jontor Village (28.21%) and Lae Ikan Village (25.64%). As medicine, the highest utilisation was found in Sikelang Village (25.64%), followed by Lae Ikan Village (23.8%) and Jontor Village (23.08%). For the function as a natural fragrance for preserving corpses, Jontor Village recorded the highest rate (30.77%), while Sikelang and Lae Ikan Villages recorded 23.08% and 20.51% respectively. As a perfume mixture, the highest use was recorded in Lae Ikan Village (17.95%), followed by Jontor Village (12.82%) and Sikelang Village (10.26%). In terms of utilisation as food, Lae Ikan village also showed the highest percentage (12.82%), while Sikelang and Jontor villages recorded 7.69% and 5.13% respectively.
Analisis Penerapan Sistem Agroforestri Kopi: Studi Lapangan Agrotech dan Perspektif Petani Di Bener Meriah Fox Jumps Over The Lazy Dog: The Quick Brown Fox Jumps Over The Lazy Dog (Isolation And Analysis Of Proteolytic Activity Of Local Actinomycetes Fro Audina Yoeliarniza; Amirunnas Amirunnas; Alia Arifina; Raudhatul Jannah; Nana Fadhliana; Nikitha Chairunnisa; Indry Malliny; Salsabila Firdausia; Cut Hadisti Arhafna; Nanda Zamzami
Jurnal Bioleuser Vol. 9 No. 2: Agustus 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v9i2.1433

Abstract

Agroforestry integrates crops, trees, and livestock to enhance land productivity and ensure sustainability. Bener Meriah Regency faces challenges in conventional coffee cultivation, including price fluctuations, pest infestations, and climate change impacts. This study analyzes the implementation of coffee agroforestry at PT. DOR Agritech and among local farmers using a descriptive qualitative method. The findings reveal that agroforestry increases farmers’ income through crop diversification, improves soil fertility, reduces dependence on chemical inputs, and strengthens ecosystem resilience. A comparison between large-scale practices and smallholder farmers highlights variations in strategies, with key challenges in waste management and companion crop selection. These results emphasize the need for policy support and locally tailored strategies to establish agroforestry as an adaptive, sustainable, and profitable model for coffee farming.
Mekanisme Stres Oksidatif dan Inflamasi Akibat Paparan Kronis PM2.5 terhadap Penurunan Fungsi Paru di Lingkungan Urban Systematic Review Zahwa Ramadani; Gita Jazila Arista; Cut Sari Ramadhani; Firdus Firdus; Muhammad Nasir; Alia Rizki
Jurnal Bioleuser Vol. 10 No. 1: April 2026
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v10i1.1444

Abstract

Exposure to fine particulate matter measuring ≤2.5 µm (PM2.5) is one of the environmental issues that significantly impacts respiratory health in urban areas. This article aims to examine the impact of chronic PM2.5 exposure on respiratory health in urban environments. This study employs a systematic literature review method using databases (Google Scholar, the National Library of Indonesia, and electronic resources) with relevant articles indexed over a 10-year period (2016–2026). The review results indicate that PM2.5 exposure is associated with an increased risk of respiratory diseases such as asthma, pneumonia, and COPD, which have a significant impact on vulnerable groups. Various mitigation strategies, such as expanding green spaces, forest conservation, controlling emissions from the transportation sector, and raising industry awareness, have led to a reduction in air pollutant levels. However, these approaches are not the primary solution, as high pollution levels reflect an imbalance between anthropogenic activities and the environment’s capacity for natural purification; therefore, additional mitigation strategies are needed to reduce the impact of PM2.5 on public health and well-being.
Penggunaan Perangkap Feromon dalam Studi Kepadatan Populasi, Kelimpahan, dan Sex Rasio Kumbang Badak Oryctes rhinoceros L. di Perkebunan Kelapa Sawit PTPN 1, Langsa, Aceh Suwarno Suwarno; Tashania Tashania; Alia Rizki; Irvianty Irvianty; Cut Nanda Defira; Zuriana Siregar; Dahelmi Dahelmi
Jurnal Bioleuser Vol. 10 No. 1: April 2026
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v10i1.1489

Abstract

This study aims to estimate the population density, abundance, and sex ratio of rhinoceros beetles (Oryctes rhinoceros L.) at different growth phases of oil palm in PTPN I plantations, Langsa Baro District. This study was conducted from June to November 2023. The method used was an experimental method. Traps were installed in four sampling blocks, each covering an area of ​​20 Ha, namely immature plants (TBM), sand fruit phase (BP), productive plants aged 4-8 years (TM 4-8) and productive plants aged >10 years (TM >10). A total of eight trap units per plant growth phase were installed systematically with a distance between traps of 400 m. The results of the study obtained 100 individuals of rhinoceros beetles in all growth phases. The average population density was 1.25 individuals/Ha and abundance was 3,125 individuals/trap. Consistent pest management carried out in PTPN I oil palm plantations is suspected to affect the results obtained. The abundance of rhinoceros beetles trapped in the BP phase was the highest (4 individuals/trap) and was significantly different from the TM (4-8) and TM (>10) phases. There were more female rhinoceros beetle imagos trapped than male imagos, with a male:female sex ratio of 1:1.64. Future studies are needed to compare this with community-owned oil palm plantations, especially regarding the population and level of rhinoceros beetle infestation.

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