<![CDATA[Background: General anesthesia accompanied by endotracheal intubation may lead to postoperative sore throat (POST). This clinical investigation aimed to assess the effectiveness of intracuff normal saline versus lignocaine in mitigating the occurrence of postoperative sore throat (POST), cough, and nausea following endotracheal intubation. Methods: This research employed a prospective, randomized, double-blind design involving 110 participants, who were allocated to two groups. Group L (n = 55) received a 2% non-alkalized lignocaine solution, whereas group S (n = 55) was administered normal saline. POST scores for both groups were recorded at 1, 3, 6, 12, and 24 hours. Additional POST-related side effects, including cough and nausea, were monitored up to 24 hours postoperatively. The Chi-square test in the Statistical Package for the Social Sciences (SPSS) version 22.0 was used to compare POST scores between groups S and L, with α set at 0.05 and a 95% confidence level. Result: The degree of POST in group S was markedly elevated at 1, 3, 6, 12, and 24 hours relative to group L (p<0.05). The incidence of postoperative cough and nausea was also higher in group S than in group L. Conclusion: The use of intracuff lignocaine demonstrates superiority over normal saline in diminishing postoperative sore throat, cough, and nausea among patients undergoing endotracheal intubation]]>
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