This study aims to describe the utilization of traditional medical plants by the people of Gilireng District, South Sulawesi. Data were obtained through structured interviews wtih five informants who hase experience using medicinal plants. The results showed that the five main plants that are often used are bay leaves (Syzygium polyanthum), guava (Psidium guajava L.), soursop (Annona muricata L.), cat’s whiskers (Orthosiphon aristatus), and lemongrass (Cymbopogon citratus). Each plant contains different active compounds, such as eugenol and kaempferol, which are believed to treat various complaints such as fever, diarrhea, headache, and high blood pressure. This knowledge has been passed down from generation to generation and is still used today. This study is the first step in preserving local knowledge for the development of nature-based medicine.
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