Objective: To examine the effectiveness of the HIV Integrated Visual Interface (HIVI) in improving antiretroviral therapy (ART) adherence among people living with HIV. Methods: A quasi-experimental pretest–posttest control group study was conducted at a private hospital in Jakarta, Indonesia. Eighty participants were recruited using purposive sampling and non-randomly allocated to intervention (n = 40) and control (n = 40) groups. Adherence was measured using the Morisky Medication Adherence Scale (MMAS-8), alongside questionnaires assessing knowledge and family support. The intervention group received HIVI for four weeks, while the control group received standard care. Data were analyzed using paired and independent t-tests and a General Linear Model (GLM). Results: ART adherence increased significantly in the intervention group (3.95 to 6.05), while the control group showed minimal change (4.00 to 4.05). Significant improvement was observed in the intervention group (p < 0.001), with no significant change in the control group (p = 0.160). Post-intervention differences between groups were significant (p < 0.001). Knowledge (p = 0.004) and family support (p = 0.020) were significant predictors of adherence. Discussion: The findings indicate that digital-based educational interventions combined with psychosocial reinforcement may enhance medication adherence by improving patient understanding, motivation, and engagement in long-term HIV treatment management. Conclusion: HIVI effectively improved ART adherence by strengthening educational and psychosocial support. The findings support HIVI as a scalable nurse-led digital intervention for improving treatment adherence among people living with HIV.
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