Louis Althusser interpretation of Marxism marks an important shift in the tradition of Marxist thought by emphasizing the epistemological break line between the work of the young Marx and the mature Marx. This break refers to Althusser's view that interprets the young Marx as an ideological figure and the mature Marx as a scientific figure. Althusser’s interpretation of Marx thought is informed by a radical change in the orientation of Marx thought by breaking away from the influence of Jeman’s classical philosophy and Feuerbach’s humanisthrough methodological and conceptual transformation. This fracture is interpreted not as a single event, but as a complex theoretical process based on historical materialism. Within the framework of this interpretation, Althusser rejects the humanist reading of Marxism by offering and alternative with a structuralist approach to emphasize the scientific production of knowledge and the strict separation of ideology and science. The research method used in this work uses philosophical hermeneutic approach by applying methodical element in the form of exploratory studies, data inference, essential analysis processing, and systematic compilation. The results of this work critically examine the concept of epistemological break put forward by Althusser and reconstruct the foundation of Marxism as a science rather than an ideology
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