MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation
Vol. 7 No. 2 (2026): June

Potential of Phytochemical Compounds from Natural Products as Anticancer Agents: A Systematic Literature Review

Saeful Amin (Bakti Tunas Husada University)
Azka Najhan (Bakti Tunas Husada University)
Aldy Arifin Ilham (Bakti Tunas Husada University)
Annisa Septiani (Bakti Tunas Husada University)



Article Info

Publish Date
31 May 2026

Abstract

Cancer is one of the leading causes of death worldwide, necessitating the development of more effective and safe anticancer therapies. Phytochemical compounds from natural sources hold great potential due to their diverse biological activities. This study aims to assess the potential of phytochemical compounds as anticancer agents through a systematic literature review of fifteen scientific articles selected based on specific inclusion criteria and analyzed qualitatively. The results indicate that compounds such as flavonoids including quercetin, polyphenols, alkaloids, and terpenoids have anticancer activity through inhibition of cell proliferation, induction of apoptosis, and inhibition of angiogenesis and metastasis, mediated by molecular pathways such as p53, nuclear factor kappa B, and caspases. In addition, approaches such as nanoformulation and combination therapy can improve the efficacy and bioavailability of the compounds. These findings indicate that phytochemical compounds have the potential to be safer and more effective anticancer agents, and require further research for clinical development

Copyrights © 2026






Journal Info

Abbrev

go

Publisher

Subject

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Description

MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation | ISSN (e): 2986-7754 is a peer-reviewed, open access journal which publishes original research articles and review articles in all areas of nursing and midwifery, research and education. The aim of the journal is to ...