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All Journal MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Journal of Engineering Science and Technology Management
Saeful Amin
Bakti Tunas Husada University
Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Dentistry Electrical & Electronics Engineering Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Potential of Phytochemical Compounds from Natural Products as Anticancer Agents: A Systematic Literature Review Saeful Amin; Azka Najhan; Aldy Arifin Ilham; Annisa Septiani
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59733/medalion.v7i2.285

Abstract

Cancer is one of the leading causes of death worldwide, necessitating the development of more effective and safe anticancer therapies. Phytochemical compounds from natural sources hold great potential due to their diverse biological activities. This study aims to assess the potential of phytochemical compounds as anticancer agents through a systematic literature review of fifteen scientific articles selected based on specific inclusion criteria and analyzed qualitatively. The results indicate that compounds such as flavonoids including quercetin, polyphenols, alkaloids, and terpenoids have anticancer activity through inhibition of cell proliferation, induction of apoptosis, and inhibition of angiogenesis and metastasis, mediated by molecular pathways such as p53, nuclear factor kappa B, and caspases. In addition, approaches such as nanoformulation and combination therapy can improve the efficacy and bioavailability of the compounds. These findings indicate that phytochemical compounds have the potential to be safer and more effective anticancer agents, and require further research for clinical development
Molecular Docking Approach to Curcumin Compounds and Its Derivatives as Anticancer Agents: A Literature Review Rani Putri Luthfiani; Nadya Nasywa Saputri; Saeful Amin
Journal of Engineering Science and Technology Management (JES-TM) Vol. 6 No. 1 (2026): Maret 2026
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v6i1.308

Abstract

Cancer remains a major global health challenge, with increasing incidence and mortality rates. This study aims to regularly review the potential of curcumin and its derivatives as anticancer agents using molecular docking approaches. A Systematic Literature Review (SLR) was conducted, analyzing ten original articles published between 2020 and 2025 from PubMed and Google Scholar. The population encompassed all full-text studies on molecular docking of curcumin and its derivatives against cancer protein targets, with purposive sampling based on inclusion and exclusion criteria. Data were extracted on ligands, protein targets, docking software, validation parameters, and binding energies, then analyzed using narrative synthesis and comparative methods. The results show that curcumin and its derivatives interact with multiple cancer-related proteins, such as EGFR, HER2, CDK2, and androgen receptors, with derivatives exhibiting more stable binding energies (−6 to −9 kcal/mol) than natural curcumin. These findings indicate that curcumin derivatives have higher anticancer activity and overcome bioavailability limitations. The conclusion highlights the need for standardized molecular docking protocols and integration with biological assays to support clinical development of curcumin-based therapies.
Co-Authors Aldy Arifin Ilham Annisa Septiani Azka Najhan Nadya Nasywa Saputri Rani Putri Luthfiani