Antidiabetic Effects of Miana (Coleus atropurpureus) Leaf Ethanol Extract on Blood Glucose and Pancreatic-Renal Histopathology in Diabetic Rats

Tien Wahyu Handayani (Department of Pharmacy, Pelita Mas College of Pharmaceutical Sciences, Palu City, Central Sulawesi, 94111)
Mariyani Mariyani (Department of Pharmacy, Pelita Mas College of Pharmaceutical Sciences, Palu City, Central Sulawesi, 94111)
Joni Tandi (Department of Pharmacy, Pelita Mas College of Pharmaceutical Sciences, Palu City, Central Sulawesi, 94111)
Cecilya Caroline (Department of Pharmacy, Pelita Mas College of Pharmaceutical Sciences, Palu City, Central Sulawesi, 94111)
Magfirah Magfirah (Department of Pharmacy, Pelita Mas College of Pharmaceutical Sciences, Palu City, Central Sulawesi, 94111)

Indonesian Journal of Jamu
Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia

This study evaluated the antidiabetic potential of ethanol extract of miana leaves (Coleus atropurpureus Benth.) and its protective effects on pancreatic and renal tissues in streptozotocin-induced diabetic rats. Thirty male Wistar rats were allocated to six groups: normal control, negative control (diabetes + Na-CMC), positive control (diabetes + glibenclamide), and three groups receiving miana extract at 150, 200, or 250 mg/kg body weight. Diabetes was induced by intraperitoneal streptozotocin injection (40 mg/kg body weight). Phytochemical screening detected flavonoids, alkaloids, tannins, and saponins. On day 28, 250 mg/kg produced the greatest blood glucose reduction (102 ± 9 mg/dL), numerically lower than glibenclamide (123 ± 25 mg/dL), although not statistically significant (p = 0.248). Histopathological analysis showed pancreatic and renal protection, with damage scores of 0.8 ± 0.447 and 0.4 ± 0.548, respectively. These findings indicate that 250 mg/kg was the most effective dose in this model.