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All Journal Indonesian Journal of Jamu
Mariyani Mariyani
Department of Pharmacy, Pelita Mas College of Pharmaceutical Sciences, Palu City, Central Sulawesi, 94111
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Antidiabetic Effects of Miana (Coleus atropurpureus) Leaf Ethanol Extract on Blood Glucose and Pancreatic-Renal Histopathology in Diabetic Rats Tien Wahyu Handayani; Mariyani Mariyani; Joni Tandi; Cecilya Caroline; Magfirah Magfirah
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.445

Abstract

This study evaluated the antidiabetic potential of ethanol extract of miana leaves (Coleus atropurpureus Benth.) and its protective effects on pancreatic and renal tissues in streptozotocin-induced diabetic rats. Thirty male Wistar rats were allocated to six groups: normal control, negative control (diabetes + Na-CMC), positive control (diabetes + glibenclamide), and three groups receiving miana extract at 150, 200, or 250 mg/kg body weight. Diabetes was induced by intraperitoneal streptozotocin injection (40 mg/kg body weight). Phytochemical screening detected flavonoids, alkaloids, tannins, and saponins. On day 28, 250 mg/kg produced the greatest blood glucose reduction (102 ± 9 mg/dL), numerically lower than glibenclamide (123 ± 25 mg/dL), although not statistically significant (p = 0.248). Histopathological analysis showed pancreatic and renal protection, with damage scores of 0.8 ± 0.447 and 0.4 ± 0.548, respectively. These findings indicate that 250 mg/kg was the most effective dose in this model.
Co-Authors Cecilya Caroline Joni Tandi Magfirah Magfirah Tien Wahyu Handayani