<![CDATA[Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by the uncontrolled proliferation of immature B-cell or T-cell lymphoid progenitors. This malignancy predominantly affects children, with a peak incidence between the ages of 2 and 5 years. Data from Indonesia show an incidence of leukemia of around 4 per 100,000 children, with an estimated 2,000-3,200 new cases per year. The survival rate for childhood leukemia in Indonesia is only around 20-30%, while in developed countries, it is nearly 90%. This article aims to explore deeply the factors influencing survival in pediatric ALL through a systematic literature review of records from 1981 to 2024. Our findings suggest that low-middle-income countries, age < 1 year, male gender, malnutrition, splenomegaly, hepatomegaly, severe anemia, leukocytosis, thrombocytopenia, high-risk stratification, and poor quality of life are linked to lower survival rates.]]>
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