<![CDATA[Erythritol, a sugar alcohol, is commercially produced through fermentation. Yarrowia lipolytica and Moniliella pollinis serve as efficient erythritol producers due to their osmotic tolerance. Optimizing the cost-effectiveness of erythritol production involves harnessing strains capable of utilizing low-cost carbon sources. This study examines the impact of two different carbon sources (glucose and molasses) on the growth and erythritol production of native and UV-induced mutant strains of Y. lipolytica and M. pollinis. In the glucose-based medium (GYM), the M. pollinis SP5 mutant strain achieved the highest erythritol biosynthesis, with a yield mass of 0.275 g/g and a volumetric productivity of 0.052 g/L/h, while in the molasses-based medium (MYM), it attained a yield mass of 0.120 g/g and a volumetric productivity of 0.065 g/L/h. Random mutagenesis might improve erythritol biosynthesis by increasing enzyme activity and altering carbon flux. Molasses emerged as a potential carbon source for M. pollinis, which favors sucrose hydrolysis and glucose metabolism for erythritol production. To further enhance erythritol yield with M. pollinis, it is advisable to increase the concentration of molasses, adjust the carbon-to-nitrogen (C/N) ratio in the MYM medium, and optimize the fermentation systems.]]>
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