<![CDATA[Diabetes mellitus is a complex chronic disease requiring continuous medical care with multifactorial risk-reduction strategies beyond glycemic control. Diabetes self-management education and support are essential to prevent acute complications, and diabetes remains a major global health concern. This study aimed to determine the relationship between patient knowledge and adherence to antidiabetic medication among diabetes mellitus patients at Ciamis Regional General Hospital. This study used a quantitative descriptive design to assess the relationship between patient knowledge and medication adherence. The research was conducted in the outpatient department of Ciamis Regional General Hospital. The study population consisted of diabetes mellitus patients receiving treatment during the study period. A total sampling technique was applied, involving 39 respondents. Data were analyzed using statihistic. The statistical analysis using the Chi-square test showed a p-value of 0.008 (p < 0.05), indicating a significant relationship between patient knowledge and adherence to antidiabetic medication. There is a significant association between patient knowledge and adherence to antidiabetic medication among diabetes mellitus patients at Ciamis Regional General Hospital.]]>
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