Biology, Medicine, & Natural Product Chemistry
Vol 15, No 1 (2026)

Evaluation of a Five-Ingredient Herbal Combination in Postpartum Hypertension and Maternal Recovery

Efri Leny Rauf (Muhammmadiyah University Gorontalo)
Fifi Ishak (Muhammmadiyah University Gorontalo)
Zuriati Muhamad (Muhammmadiyah University Gorontalo)
Rosmin Ilham (Muhammmadiyah University Gorontalo)



Article Info

Publish Date
06 Jul 2026

Abstract

Postpartum hypertension represents a persistent contributor to maternal morbidity and mortality across developing regions. This quasi-experimental pretest–posttest study evaluated the efficacy of a five-component polyherbal formulation consist of red ginger (Zingiber officinale var. rubrum), garlic (Allium sativum), lemon (Citrus limon), apple-cider vinegar, and honey in improving hemodynamic stability and postpartum recovery. Sixty-two postpartum women at Prof. Dr. H. Aloei Saboe Hospital, Gorontalo, Indonesia, were equally stratified into hypertensive and normotensive subgroups. Participants ingested 5 mL of the standardized mixture twice daily for six weeks. Weekly monitoring assessed blood pressure, lactation adequacy, lochia characteristics, and uterine involution. Statistical analysis using the Wilcoxon signed-rank and chi-square tests confirmed significant reductions in mean systolic (153.55 ± 9.72 -> 120.32 ± 6.84 mmHg) and diastolic (98.39 ± 7.41 -> 79.68 ± 5.96 mmHg) pressures among hypertensive participants (p < 0.001). No significant variations occurred in lactation (p = 0.209) or uterine involution (p = 0.319), whereas lochia normalization exhibited positive association (p < 0.05). No adverse events were reported. The outcomes substantiate the formulation’s antihypertensive and restorative efficacy via antioxidative and vasodilatory mechanisms. Its safety, affordability, and cultural acceptability demonstrate translational potential as an adjunct in postpartum hypertension management. Further controlled, biomarker-based studies are warranted to validate long-term efficacy and mechanistic precision.

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Journal Info

Abbrev

BIOMEDICH

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Description

BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for ...