Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Vol 76 No 1 (2026): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo

Prevalensi Kanker Paru pada Pasien Riwayat Tuberkulosis di Indonesia: Sebuah Tinjauan Sistematis dan Meta-Analisis

Arya Marganda Simanjuntak (Research Assistant, Pulmonary and Critical Medicine Division, Department of Internal Medicine, Faculty of Medicine, Universitas Riau, Arifin Achmad General Hospital, Pekanbaru, Riau)
Elvando Tunggul Mauliate Simatupang (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Riau, Arifin Achmad General Hospital)
Sri Melati Munir (Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Riau, Arifin Achmad General Hospital, Pekanbaru)
Indra Yovi (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Riau, Arifin Achmad General Hospital)
Rohani Lasmaria Simbolon (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Riau, Arifin Achmad General Hospital)



Article Info

Publish Date
23 Jun 2026

Abstract

Introduction: Indonesia faces a 14% increase in Tuberculosis (TB) cases, putting it 14 years behind the world's second-highest burden. This raises concerns about lung cancer risk, as studies outside Indonesia are limited.Aim: This study aims to determine the risk of lung cancer in TB patients in Indonesia.Methods: This systematic review with meta-analysis according to PRISMA statement with various databases. We use PEOS framework for screening and select articles to be included. We exclude articles about co-infection TB with lung cancer and misdiagnose condition. We analyze risk of bias using JBI critical appraisal tools and we used R Studio and RevMan 5.4 with random-effect model for results of data that can be generalized on a wider population.Result: There are 3 out of 4210 articles with 1270 patients included in this study. The research came from different cities and extracted the number of patients that matched the criteria. A total of 101 (7.9%) of 1270 lung cancer patients had a history of tuberculosis. There are 8 out of 100 lung cancer patients in Indonesia had TB infection before and is dominated by the type of adenocarcinoma compared to squamous cell carcinoma (statistically not meaningful, p=0.21). This study was evaluated as heterogeneous among all inclusion studies. The risk rate of bias with the JBI was 76.6% above the risk limit of the bias agreement.Conclusion: Patients with a history of TB need future attention and further evaluation before the occurrence of lung cancer.

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Journal Info

Abbrev

jurnal

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

Description

Journal Of The Indonesian Medical Association (JInMA) / Majalah Kedokteran Indonesia (MKI) adalah Jurnal yang berada di bawah naungan Pengurus Besar Ikatan Dokter Indonesia (PB IDI) dan sebagai Kanal InformasiIlmiah di Kalangan Dokter Umum dan Dokter Spesialis serta Profesi ...