Biodiversitas Journal of Biological Diversity
Vol. 7 No. 4 (2006)

The Effect of Oral Administration of Fermented Rice by Monascus purpureus JmbA on Blood of Hypercholesterolemia White Mouse (Rattus sp.)

EVI TRIANA (Balai Penelitian Mikrobiologi, Pusat Penelitian Biologi, Lembaga Ilmu Pengetahuan Indonesia (LIPI), Bogor 16002)
NOVIK NURHIDAYAT (Balai Penelitian Mikrobiologi, Pusat Penelitian Biologi, Lembaga Ilmu Pengetahuan Indonesia (LIPI), Bogor 16002)



Article Info

Publish Date
30 Sep 2006

Abstract

Fermented rice by Monascus purpureus, namely angkak, produces lovastatin. Lovastatin is believed and studied as anti-hypercholesterolemic agent. Somehow, its effects on blood parameters were less known. Therefore, a study on the effect of angkak on erythrocyte, leukocyte, thrombocyte, and haemoglobin level was conducted, involving 15 male Sprague Dawley strain white mice that were divided into 5 treatment groups. The result showed that oral administration of angkak beared lovastatin to the hipercholesterolemic mice could increase the number of trombocyte during the study. Increasing the number of thrombocyte was different depended on dosage of angkak. The optimum dosage was 0.1 g/day. Angkak could also increase haemoglobin concentration and the number of leucocyte, although that raise did not depend on dosage of angkak. Meanwhile, the number of erythrocyte was not affected by angkak.Key words: angkak, erythrocyte, hemoglobin, leukocyte, lovastatin, thrombocyte

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Journal Info

Abbrev

biodiv

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

Description

The Biodiversitas Journal was first published in 2000 by the Department of Biology, FMNS, Universitas Sebelas Maret, Surakarta, Indonesia, then in 2006 it was co-published by the Society for Indonesian Biodiversity and that department; since 2017 it was also hosted by Smujo. From 2003-2012 it was ...