The role of VDR and TNF gene polymorphism in cytokine regulation in type I diabetes mellitus of the Uzbek population, Samarkand, Uzbekistan

FARIZA RAYIMOVA (Department of Genetics and Biotechnology, Institute of Biochemistry of Samarkand State University named after Sharof Rashidov. University Boulevard 15, 140104 Samarkand, Uzbekistan)
GAVHAR DUSHANOVA (Department of Genetics and Biotechnology, Institute of Biochemistry of Samarkand State University named after Sharof Rashidov. University Boulevard 15, 140104 Samarkand, Uzbekistan)
BEGALI ALIKULOV (Department of Genetics and Biotechnology, Institute of Biochemistry of Samarkand State University named after Sharof Rashidov. University Boulevard 15, 140104 Samarkand, Uzbekistan)
ZAYNITDIN KAMALOV (Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan. Str. Yahyo Gulyamov 74, 100060 Mirabad, Tashkent, Uzbekistan)
MALIKA RUZIBAKIEVA (Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan. Str. Yahyo Gulyamov 74, 100060 Mirabad, Tashkent, Uzbekistan)
FARANGIZ NABIYEVA (Department of Clinical and Laboratory Diagnostics, Samarkand State Medical University. 18 Amir Temur Str. 140104 Samarkand, Uzbekistan)
ASATILLO RAJABOV (Department of Human and Animal Physiology and Biochemistry, Samarkand State University named after Sharof Rashidov. University Boulevard 15, 140104 Samarkand, Uzbekistan)

Biodiversitas Journal of Biological Diversity
Vol. 25 No. 3 (2024)

Abstract. Rayimova F, Dushanova G, Alikulov B, Kamalov Z, Ruzibakieva M, Nabiyeva F, Rajabov A. 2024. The role of VDR and TNF gene polymorphism in cytokine regulation in type I diabetes mellitus of the Uzbek population, Samarkand, Uzbekistan. Biodiversitas 25: 1329-1336. After 2000, diabetes became one of the most common diseases in the world. Special attention is paid to the research to determine the variability of genetic processes in patients in the origin and development of this disease. The article is devoted to the study of the connection between the polymorphism of genotypes GG, GA, AA polymorphism BsmI of the VDR- (Vitamin D receptor) gene and GG, GA of the TNF-A-308G/A- (Tumor necrosis factor A) gene with the regulation of cytokines TNF? and IL6-Interleykin 6 in sick and healthy individuals of the Samarkand region of the Uzbek population. The analysis of the BsmI polymorphism of the VDR gene and TNF-A-308G/A indicates the involvement of certain genotypes in the Type 1 Diabetes Mellitus (T1DM) pathogenesis. The age of onset of the disease in the studied population is from 7 years, but the increase in the incidence of diseases begins from 10 years. Type 1 diabetes is more common in females. Studies of the relationship between the cytokines TNF? and IL6 show their high content depending on the genotypes GG, GA, and AA of the BsmIA polymorphism of the VDR gene and the genotypes GG and GA of the gene. TNF-A-308G/A. However, the highest rates were recorded in individuals with the AA genotype of the BsmI polymorphism of the VDR gene. The obtained results can serve as fundamental knowledge in revealing and explaining the mechanisms of cytokinin control in people with diabetes in different populations of the same nation.