Review Article: The Potential of Terpenoids from Marine Organisms as Neuroprotective Agents in Peripheral Neuropathy

Shafira Adinda Putri (Department of Medicine, Faculty of Medicine and Health Sciences, Mataram University, West Nusa Tenggara, Indonesia.)
Baiq Rizqika Catur Putri (Department of Medicine, Faculty of Medicine and Health Sciences, University of Mataram, West Nusa Tenggara, Indonesia.)
Mulayanatul Aliyyah (Department of Medicine, Faculty of Medicine and Health Sciences, University of Mataram, West Nusa Tenggara, Indonesia.)
Fito Danang Sofiandi (Department of Medicine, Faculty of Medicine and Health Sciences, University of Mataram, West Nusa Tenggara, Indonesia)
Ilsa Hunaifi (Department of Neurology, Faculty of Medicine and Health Sciences, University of Mataram, West Nusa Tenggara, Indonesia)

Lombok Medical Journal
Vol. 5 No. 3 (2026): Lombok Medical Journal (InPress)

Peripheral neuropathy is a common neurological disorder, particularly in patients with diabetes mellitus and older adults, with limitations of current therapies prompting the search for alternative treatments. This narrative review aims to evaluate the potential of marine-derived terpenoids as neuroprotective agents in peripheral neuropathy. Terpenoids demonstrate multi-target mechanisms, including antioxidant and anti-inflammatory effects, ion channel modulation, and regulation of signaling pathways such as phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), Mitogen Activated Protein Kinase (MAPK), and nuclear factor erythroid 2 related factor 2 (Nrf2). These actions contribute to reduced oxidative stress, suppression of neuroinflammation, and improved neuronal survival. Compounds such as astaxanthin show promising effects in reducing neuropathic pain, although evidence remains largely preclinical. Clinical translation is limited by low bioavailability and insufficient long term safety data. Further studies are required to confirm their therapeutic potential.