The intensification of fish farming has led to a high risk of disease outbreaks due to environmental stress and declining water quality. Excessive use of antibiotics has caused problems with antimicrobial resistance, making it necessary to develop more sustainable alternatives for disease control through a nutritional approach. This study aims to analyze the effect of nutrition on the immune response and disease resistance in farmed fish through a literature review. The results of the review indicate that proteins, amino acids, lipids, vitamins, and minerals play a crucial role in enhancing the function of the fish immune system. Additionally, probiotics, prebiotics, synbiotics, phytogenics, and antioxidants in feed can enhance the nonspecific immune response, maintain the balance of gut microbiota, and improve fish resistance to pathogen infections. Thus, the use of immunostimulant-based functional feed is an effective strategy for supporting fish health and the development of sustainable aquaculture.
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