<![CDATA[Predicting lung disease recurrence from longitudinal clinical data remains challenging because irregular temporal patterns and heterogeneous patient characteristics reduce the effectiveness of conventional deep learning models. This study analyzes a hybrid Deep Neural Network (DNN)–Bidirectional Long Short-Term Memory (BiLSTM) framework for the longitudinal prediction of lung disease recurrence using clinical data collected between 2021 and 2024 from a referral hospital in Gorontalo. The dataset includes demographic information, laboratory examination results, clinical diagnoses, and longitudinal medical records. Lung disease recurrence is defined as the reappearance or worsening of the disease during longitudinal clinical follow-up after the initial diagnosis or treatment. The proposed framework combines DNN to learn complex nonlinear relationships among multivariate clinical features and BiLSTM to capture temporal dependencies across sequential patient observations. Model performance was evaluated using Accuracy, Precision, Recall, F1-score, and Root Mean Square Error (RMSE), and compared with standalone DNN and BiLSTM models. Experimental results demonstrate that the proposed hybrid framework consistently outperformed the individual models, achieving an improvement of approximately 7–10% across the evaluation metrics while providing more stable longitudinal prediction performance. Furthermore, multivariate analysis identified dominant clinical variables associated with lung disease recurrence, improving the interpretability of prediction results for clinical decision-making. These findings indicate that the proposed framework provides an effective computational approach for longitudinal clinical prediction and supports the development of intelligent clinical decision support systems for recurrence risk assessment]]>
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