<![CDATA[Introduction: Hypertension remains a major global public health challenge and a leading risk factor for cardiovascular morbidity and mortality. In addition to pharmacological therapy, dietary and natural product-based interventions have gained increasing attention as complementary strategies for blood pressure control. Passiflora edulis (passion fruit) contains bioactive compounds with potential antihypertensive properties; however, clinical evidence supporting its effectiveness remains limited. Objective: This study aimed to examine the effect of Passiflora edulis juice consumption on systolic and diastolic blood pressure among patients with hypertension. Methods: A randomized, double-blind, placebo-controlled trial was conducted among hypertensive patients attending an outpatient clinic in Indonesia. Participants were randomly assigned to receive either Passiflora edulis juice or a placebo beverage daily for a predefined intervention period. Systolic and diastolic blood pressure were measured at baseline and follow-up using standardized procedures. Data were analyzed using linear mixed-effects models to assess changes in blood pressure over time between groups, adjusting for relevant baseline covariates. All analyses followed the intention-to-treat principle. Results: Participants in the Passiflora edulis juice group demonstrated a significant reduction in both systolic and diastolic blood pressure compared with the placebo group over the intervention period. The group × time interaction effect was statistically significant (p 0.05), indicating greater blood pressure reduction among participants who consumed Passiflora edulis juice. No serious adverse events related to the intervention were reported. Conclusion: Daily consumption of Passiflora edulis juice was effective in reducing systolic and diastolic blood pressure among hypertensive patients. These findings suggest that Passiflora edulis juice may serve as a safe and beneficial complementary dietary intervention for hypertension management. Further large-scale and long-term studies are recommended to confirm these findings and explore underlying mechanisms.]]>
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