<![CDATA[Anemia in adolescent girls can have many adverse effects, such as decreased fitness, reduced academic performance, and increased risk during future pregnancies. One way to prevent it is by taking iron pills, also known as blood-boosting tablets. The research aimed to determine the association between knowledge and compliance with blood supplement tablet consumption and the Incidence of Anemia. The methodology of this research employed an analytical survey design, utilizing a cross-sectional approach. All female students in grades VII, VIII, and IX at Junior High School 10 Sekayu in 2025 were included in the study, totaling 66 students. Data analysis used the Chi-square test with α=0.05 to test the relationship between variables. The results of the study showed a significant relationship between the variable association between knowledge with Anemia Incidence (p-value=0.001). The variable Compliance with Iron Tablet Consumption and the incidence of anemia showed a significant relationship (p-value=0.004). Adherence to iron supplementation has been shown to be crucial for successful anemia prevention, but other factors such as dietary intake, nutritional status, comorbidities, and environmental support are also important. Efforts to improve knowledge and compliance with iron supplement consumption need to be continuously carried out, supported by schools, health workers, and families.]]>
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