<![CDATA[Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood sugar levels that can damage various organs, including the heart, blood vessels, kidneys, and nerves. Diagnosing DM typically involves assessing blood glucose levels and hemoglobin A1c (HbA1c), which reflects average glucose levels over the past 2 to 3 months. HbA1c testing has limitations, including interference from red blood cell lifespan, relatively high costs, and limited availability in some laboratories in Indonesia. Hematology parameters are crucial for diagnosis, including hematocrit, which is associated with blood viscosity, inflammation, and hyperinsulinemia. These conditions are closely associated with the clinical state of Diabetes mellitus. This research aims to analyze the association between hematocrit and HbA1c to identify alternative tests for predicting glycemic status. A cross-sectional study was conducted among 603 patients with diagnosed type 2 diabetes who visited the outpatient department at Al Islam Hospital from January 2018 to December 2019, selected through total sampling. Data were analyzed using multiple linear regression to assess the association between hematocrit and HbA1c, adjusting for confounders. A p-value <0.05 was considered statistically significant. The mean hematocrit level is 41.23±6.21, and HbA1c is 7.87±2.49. The results demonstrated a positive association between increased hematocrit and increased HbA1c, although the effect size is small and statistically insignificant after adjusting for age and sex (β=0.03; 95% CI=−0.004, 0.06; p=0.08; adjusted R-squared=0.004), where an increase of 1 unit of hematocrit is associated with a rise of 0.03 units of HbA1c in this study. In conclusion, hematocrit levels cannot yet serve as a substitute for HbA1c for assessing a patient’s glycemic status.]]>
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