Journal of Biomedicine and Translational Research
Vol 12, No 2 (2026): August 2026

Retinal Thickness After Platelet Rich Plasma Injection in Glaucoma Model Rats

Syifa Thifal Umaira (Master Program in Departement of Biology, Faculty of Mathematics and Science, Syiah Kuala University)
Rosnizar Rosnizar (Departemet of Biology, Faculty of Mathematics and Science, Syiah Kuala University, Banda Aceh)
Siti Hajar (Departement of Opthalmology, Faculty of Medicine, Syiah Kuala University, Banda Aceh)
Widya Sari (Departemet of Biology, Faculty of Mathematics and Science, Syiah Kuala University, Banda Aceh)
Dessy Rakhmawati Emril (Departement of Neurology, Faculty of Medicine, Syiah Kuala University, Banda Aceh)



Article Info

Publish Date
31 Aug 2026

Abstract

Platelet-rich plasma (PRP) is an autologous blood component that contains a high concentration of platelets. PRP is known contains growth factors that play roles in cell regeneration, proliferation, and differentiation. This study used a completely randomized design (CRD) consisting of 5 groups and 5 repetitions. The test animals used were 25 male Wistars rats aged 2 months. The animal model of glaucoma was given 250 mmHg pressure on the right eye for 60 minutes and PRP was given 7 days after the pressure was increased. Then the thickness of the eye retina was observed after 8 weeks. The eye of the test animals were collected and made into histology preparations using paraffin method and Hematoxylin Eosin (HE) staining. Data were analyzed using ANOVA test with a significant level of 5% and continued with Duncan’s multiple tests. The result showed that there was a significant effect of PRP injection on the retinal thickness in the inner plexiform layer. Intravitreal-intraperitoneal injection of PRP is an effective injection route because it is capable of repairing damage based on the results of the thickness of the inner plexiform layer.

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Journal Info

Abbrev

jbtr

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Description

Journal of Biomedicine and Translational Research (JBTR) is an open access, international peer-reviewed journal that considers articles on: clinical medicine, molecular medicine, tropical medicine, infectious diseases, cardiovascular medicine, molecular biology, genetics, immunology, microbiology, ...