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All Journal Journal of Biomedicine and Translational Research
Rosnizar Rosnizar
Departemet of Biology, Faculty of Mathematics and Science, Syiah Kuala University, Banda Aceh
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Retinal Thickness After Platelet Rich Plasma Injection in Glaucoma Model Rats Syifa Thifal Umaira; Rosnizar Rosnizar; Siti Hajar; Widya Sari; Dessy Rakhmawati Emril
Journal of Biomedicine and Translational Research Vol 12, No 2 (2026): August 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i2.28806

Abstract

Platelet-rich plasma (PRP) is an autologous blood component that contains a high concentration of platelets. PRP is known contains growth factors that play roles in cell regeneration, proliferation, and differentiation. This study used a completely randomized design (CRD) consisting of 5 groups and 5 repetitions. The test animals used were 25 male Wistars rats aged 2 months. The animal model of glaucoma was given 250 mmHg pressure on the right eye for 60 minutes and PRP was given 7 days after the pressure was increased. Then the thickness of the eye retina was observed after 8 weeks. The eye of the test animals were collected and made into histology preparations using paraffin method and Hematoxylin Eosin (HE) staining. Data were analyzed using ANOVA test with a significant level of 5% and continued with Duncan’s multiple tests. The result showed that there was a significant effect of PRP injection on the retinal thickness in the inner plexiform layer. Intravitreal-intraperitoneal injection of PRP is an effective injection route because it is capable of repairing damage based on the results of the thickness of the inner plexiform layer.
Co-Authors Dessy Rakhmawati Emril Siti Hajar Syifa Thifal Umaira Widya Sari