<![CDATA[Background: Non-communicable diseases, such as hypertension and diabetes mellitus, represent a significant global health issue, leading to the establishment of the Chronic Disease Management Program (Prolanis). Long-term medication use among Prolanis patients can lead to treatment fatigue, which may decrease adherence to proper medication use, including the consideration of Beyond Use Date (BUD). Failure to adhere to BUD guidelines poses risks to medication stability, efficacy, and patient safety. This study aimed to determine the influence of BUD education, provided via leaflets, on the knowledge, attitude, and practice (KAP) of Prolanis patients at RSI Sultan Agung Semarang. Methods: This study employed a quasi-experimental design with a one-group pretest-posttest approach. A total of 40 respondents were selected using total sampling based on established inclusion and exclusion criteria. Data were collected using questionnaires to assess knowledge, attitude, and practice before and after the educational intervention. The data were analyzed using univariate, normality, and bivariate (Paired T-Test or Wilcoxon) tests to evaluate the impact of the intervention. Results: The study identified that Prolanis patients often lacked sufficient understanding regarding BUD compared to manufacturer-determined expiration dates. The educational intervention, delivered through leaflets and supported by presentations, aimed to improve patient awareness and behaviors regarding the storage, use, and disposal of medications. Conclusion: The provision of education through media, such as leaflets, is an effective strategy for pharmacists to enhance Prolanis patients' understanding of BUD, thereby promoting safer and more effective medication use in accordance with the principles of halalan thayyiban (safe and halal).]]>
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