<![CDATA[ABSTRACT Background : Space Occupying Lesions (SOL) are pathological abnormalities within the intracranial space that can cause progressive neurological disorders. Intracranial SOL include cerebral contusions, hematomas, infarctions, abscesses, and tumors that grow in the intracranial space. According to the World Health Organization (WHO) 2021, glioblastoma is defined as a wild type isocitrate dehydrogenase (IDH) astrocytic tumor or grade 4 glioma, as determined by histological features and molecular markers. Glioblastoma is commonly found in the frontal, temporal, and parietal lobes. Patients with brain tumors often present as neuroemergencies due to increased intracranial pressure. Glioblastoma can be detected using a CT (Computed Tomography) scan or atau MRI (Magnetic Resonance Imaging) as the initial imaging modality. Case Description : A 43 year old man presented to the Emergency Department complaining of headaches that had persisted more than two weeks. The headaches had been persistent throughout the day and were progressively worsening. A neurological examination revealed compos mentis consciousness with left hemiparesis. A non-contrast head CT scan was performed, suggesting a cerebral abscess (DD)/cystic glioma. A contrast-enhanced CT scan revealed a diagnosis of glioblastoma multiforme. A craniotomy was performed, and the post-operative tissue section underwent pathologic examination, which concluded epithelioid glioblastoma and metastatic poorly differentiated carcinoma. Conclusions: Although brain imaging suggests glioblastoma, a definitive diagnosis cannot be made on the basis of radiographs due to their limitations in assessing the tumor's histological and molecular characteristics. In the latest WHO classification, the diagnosis of glioblastoma encompasses both histological features and molecular. These findings cannot be assessed solely on radiographs, necessitating tissue examination. Keywords: Brain Tumor, Glioblastoma,CT Scan]]>
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