<![CDATA[Joint pain is a common musculoskeletal condition that can significantly reduce mobility, physical function, and quality of life. Despite the availability of conventional analgesics, their long-term use is often associated with adverse effects, highlighting the need for safer therapeutic alternatives. Genjer (Limnocharis flava), a medicinal plant rich in flavonoids, phenolic compounds, and other bioactive constituents, has shown potential analgesic and anti-inflammatory activities, making it a promising natural candidate for the management of joint pain. Therefore, investigating the therapeutic potential of L. flava is important for the development of safer and more effective treatments for joint pain. Objective: This study aimed to determine the anti-joint pain activity of genjer extract in AgNO₃-induced rats and evaluate its effectiveness at different dose levels. Method: The experiment was conducted using four treatment groups: negative control (CMC-Na), positive control (diclofenac sodium), genjer extract at a dose of 100 mg, and genjer extract at a dose of 200 mg. The observed parameters included limping score, paw usage, mechanical hyperalgesia, and joint swelling at 30, 60, 90, and 120 minutes after treatment. Results: The positive control group showed the greatest reduction in pain scores among all groups. Both doses of genjer extract also reduced pain compared with the negative control, and the 200 mg dose produced a stronger effect than the 100 mg dose. These findings suggest that genjer extract has antinociceptive activity by reducing sensitivity to mechanical pain. However, all treatment groups showed only slight reductions in joint swelling. Conclusion: Genjer extract exhibited anti-joint pain activity in AgNO₃-induced rats. The most effective dose was 200 mg, which showed greater pain-relieving activity compared to the 100 mg dose. ]]>
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