JSFK (Jurnal Sains Farmasi & Klinis)
Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026

Nanoemulgel Based Delivery of Pometia pinnata Leaf Extract as a Potent Antioxidant

Larysa Fernenda (Department of Pharmacy, Faculty of Pharmacy, Abdurrab University)
Kony Putriani (Department of Pharmacy, Faculty of Pharmacy, Abdurrab University)
Asiska Permata Dewi (Departement of Health Analysis, Faculty of Health Science, Abdurrab University)
Elsa Nurita (Department of Pharmacy, Faculty of Pharmacy, Abdurrab University)
Bintang Indragiri (Department of Pharmacy, Faculty of Pharmacy, Abdurrab University)
Yandi Syukri (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia)



Article Info

Publish Date
21 Aug 2026

Abstract

This study aimed to formulate and evaluate a nanoemulgel containing ethanol extract of Pometia pinnata leaf as a topical antioxidant preparation. The extract was obtained through maceration using 96% ethanol, then formulated into a nanoemulsion and incorporated into a gel base containing Carbopol 940 at concentrations of 0.5%, 1%, and 2%. The evaluations included organoleptic test, homogeneity, pH, spreadability, viscosity, physical stability, and antioxidant activity, using the DPPH method with IC₅₀ as the parameter. The results showed that all formulations met acceptable physical criteria.  The pH values ranged from 4.86 to 5.49, while the spreadability ranged from 4.81 to 5.95 cm. The best formulation was the nanoemulgel containing 2% Carbopol, which showed an IC₅₀ value of 88.78 ppm, indicating strong antioxidant activity. These findings suggest that the Pometia pinnata ethanolic leaf extract nanoemulgel has promising potential as a topical antioxidant formulation for preventing premature skin aging.

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Journal Info

Abbrev

jsfk

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun ...