Background: Hypertension is a major risk factor for stroke, which may lead to disability and death. Stroke prevention behavior among hypertensive patients is influenced by several factors, including knowledge and self-efficacy; adequate knowledge of stroke and its risk factors increases patients’ awareness of preventive action, while high self-efficacy strengthens patients’ confidence to consistently practice a healthy lifestyle. Purpose: To determine the relationship between knowledge and self-efficacy with stroke prevention behavior among hypertensive patients in the working area of Ponre Public Health Center. Methods: This study used a quantitative design with a cross-sectional approach. The population comprised all 6,103 hypertensive patients in the working area of Ponre Public Health Center; the Slovin formula yielded a sample of 98 respondents. Knowledge was measured using the Stroke Prevention Knowledge Questionnaire (SPKQ), self-efficacy using the General Self-Efficacy Scale (GSES), and stroke prevention behavior using a questionnaire adapted from Riskesdas 2018. Data were analyzed using univariate and bivariate (Chi-Square) analysis. Results: The Chi-Square test showed p = 0.000 (p < 0.05) for both the knowledge–behavior and self-efficacy–behavior relationships, indicating a significant association between knowledge and self-efficacy with stroke prevention behavior among hypertensive patients in the working area of Ponre Public Health Center. Conclusion: The higher the knowledge and self-efficacy of hypertensive patients, the better their stroke prevention behavior; continuous health education and support are needed to improve patients’ knowledge and self-efficacy in preventing stroke.
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