JOURNAL OF Pharmacy and Tropical Issues
Vol. 6 No. 4 (2026): August edition 2026

Analisis efektivitas gel silver nanopartikel (AgNPs) berbasis ekstrak daun Eucalyptus terhadap percepatan penyembuhan luka pasca sirkumsisi

Nasrullah Amin (Universitas Malahayati)
Rinto Hardiarto (Universitas Malahayati)
Debi Arivo (Universitas Malahayati)
Dwi Marlina Syukri (Universitas Malahayati)



Article Info

Publish Date
29 Aug 2026

Abstract

Background: Circumcision is a minor surgical procedure requiring optimal wound care to prevent inflammation and infection and to accelerate the healing process. Silver nanoparticles (AgNPs) synthesized using *Eucalyptus* leaf extract possess antibacterial and anti-inflammatory properties that have the potential to accelerate wound healing. Purpose: To determine the effectiveness of AgNP gel based on *Eucalyptus* leaf extract on post-circumcision wound healing. Method: This study employed an experimental design with a quantitative approach, involving a sample of 20 respondents aged 7 to 13 years who underwent circumcision; the sample was selected using the total sampling technique. Data were collected through direct observation of the wound condition following the circumcision procedure. Data analysis was performed using the Chi-square test with a significance level of 0.05.Results: Application of the AgNP gel reduced the levels of inflammation and exudate. Chi-square test results indicated a significant association between pre- and post-treatment conditions. Significant differences were observed in the levels of inflammation (p=0.010) and exudate (p<0.001). Conclusion: The use of a silver nanoparticle (AgNP) gel based on *Eucalyptus* leaf extract has proven effective in accelerating the post-circumcision wound healing process in children. Following treatment, significant reductions were observed in various wound healing parameters including the degree of inflammation, redness, and exudate as well as a decrease in wound diameter.   Keywords: Silver Nanoparticles; Agnps, Eucalyptus; Circumcision; Wound Healing.

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Journal Info

Abbrev

pti

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal penelitian dibidang kesehatan meliputi ilmu keparmasian. Penelitain sesuai tren pengobatan sesuai sumber alam di negara tropis. Pengembangan obat dan pendistribusian kepada pelanggan, dan sesuai aturan Badan Pengawas Obat dan Makanan (BPOM) - Republik ...