<![CDATA[Technological development in the globalization era requires integration of digital media into learning. Students need interactive learning materials that support independent study; therefore, this research aims to develop a scientific-approach-based electronic worksheet (e-LKPD/ Lembar Kerja Peserta Didik Elektronik) on Biotechnology Material. The e-worksheet hopefully valid and effective in improving tenth-grade students’ Critical Thinking Skills (CTS) and Science Process Skills (SPS). This study employed a Research and Development (R&D) method using the 4D model, consisting of Define, Design, Develop, and Disseminate stages. The collected data include validity, readability, and the effectiveness of the e-LKPD in enhancing students’ critical thinking and science process skills. A small-scale trial was conducted at SMAN 8 Semarang, while a large-scale trial took place at SMAN 14 Semarang, based on school readiness. The results indicate that the e-LKPD is highly valid according to material and media experts and demonstrates excellent readability based on teacher and student evaluations. Furthermore, the e-LKPD proved effective in improving students’ critical thinking and science process skills into a high category. This research implies that the e-LKPD can serve as a biology learning supplement, functioning both as a biotechnology practicum guide for students and as an supplementary resource for biotechnology learning for teachers.]]>
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