<![CDATA[Background: Pre-eclampsia is one of the main causes of maternal morbidity. Hyperglycemia is thought to play a role in the pathogenesis of pre-eclampsia through the mechanisms of endothelial dysfunction and oxidative stress. Objective: To determine the relationship between random blood glucose levels (GDS) and the incidence of pre-eclampsia in pregnant women. Method: Quantitative study with a case-control design and a retrospective time approach. A sample of 140 respondents consisted of 70 pregnant women with pre-eclampsia who were taken using a total sampling technique as a case group and 70 normal pregnant women who were taken using a simple random sampling technique as a control group. The study was conducted at the Nogosari Community Health Center, Boyolali Regency with medical records of pregnant women who underwent examinations during 2025 as instruments. Analysis used the Chi-Square test. Results: There were 19 pregnant women with preeclampsia, with 13.57% having a high GDS, 10.78% having a normal GDS, 2.14% not having preeclampsia, and 47.85% not having preeclampsia. The chi-square test showed a p value of 0.001 (<0.05) with an OR of 8.32. Conclusion: There is a significant relationship between GDS levels and the incidence of preeclampsia. Pregnant women with a high GDS have an 8.32 times greater risk of developing preeclampsia.]]>
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