Patient safety is a core component of high-quality healthcare provision. A patient safety–oriented culture plays a vital role in reducing adverse events, enhancing care quality, and promoting patient-centered services. This study sought to evaluate the patient safety culture at Kendari City Regional General Hospital and to identify dimensions representing key strengths and areas for improvement. A quantitative cross-sectional survey design was applied, involving 100 respondents from both clinical and non-clinical service units. Data were collected using the Hospital Survey on Patient Safety Culture (HSOPSC 1.0) instrument, comprising twelve safety culture dimensions. The findings showed that the overall mean positive response rate for patient safety culture was 61%, indicating a good level of implementation. Key strengths were observed in organizational learning (92%), management support for patient safety (89%), and teamwork within units (89%). In contrast, weaker performance was found in the non-blaming approach to errors (37%), inter-unit collaboration (48%), and patient handover and transition processes (10%). Conclusion: The Kendari City Regional General Hospital has a solid foundation of patient safety culture; however, strengthening is required in non-punitive reporting systems, cross-unit communication, and standardization of patient handover processes to sustainably prevent patient safety risks
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