<![CDATA[Breast cancer education from adolescence is important for building early awareness of risk factors, warning signs, and preventive behavior. This study examined the effect of virtual reality (VR)-based health education on adolescents' knowledge of breast cancer prevention. A quantitative pre-experimental one-group pretest-posttest design was conducted at the Department of Nursing, Poltekkes Kemenkes Makassar, from March to August 2026. Twenty first- and second-year students aged 17–20 years participated. Knowledge was measured using a closed-ended questionnaire before and after a VR education session. Descriptive statistics summarized participant characteristics and knowledge categories, while a paired t-test assessed the difference in mean scores. Before the intervention, 55.0% of participants had poor knowledge, 40.0% had moderate knowledge, and 5.0% had good knowledge. After the intervention, 95.0% had good knowledge and 5.0% had moderate knowledge. The mean score increased from 54.50 ± 11.46 to 87.50 ± 8.51, a mean difference of 33.00 points (p < 0.001). VR-based education was associated with a significant improvement in breast cancer prevention knowledge. However, controlled studies with larger samples and follow-up measurements are required to establish causal effects and knowledge retention.]]>
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