<![CDATA[Root canal infections are one of the main problems in endodontics, largely caused by Gram-negative anaerobic bacteria, like Prevotella intermedia, which is frequently found in necrotic pulp, periapical abscesses and chronic root canal infections. Root canal irrigation is essential for eliminating microorganisms; however, conventional agents such as sodium hypochlorite have several side effects, necessitating the use of safe and effective natural, one of which is pa-paya seed extract (Carica papaya L). This study investigated whether papaya seed extract, when used as an irrigant, can inhibit the growth of P.intermedia. This laboratory experimental study, employing a post-test control design, utilised samples of 5%, 20% and 30% papaya seed extract, alongside 2.5% sodium hypochlorite and distilled water as the control. The disc diffusion method was employed to assess inhibitory activity on Mueller-Hinton agar media inoculated with P.intermedia, with five replicates for each treatment. Data were analysed using one-way ANOVA and LSD post hoc tests. Pa-paya seed extract at all concentrations exhibited inhibitory activity against the growth of P.intermedia, the greatest was observed at the 15% concentration, followed by 10% and 5% (p<0.05). It is concluded that papaya seed extract effectively inhibits the growth of P.intermedia and has the potential to be used as an alternative irriga-gation agent in root canal treatment.]]>
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