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All Journal MDJ (Makassar Dental Journal)
Indrya Kirana Mattulada
Bagian Konservasi Gigi, Fakultas Kedokteran Gigi Universitas Muslim Indonesia, Makassar, Indonesia
Dentistry

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Antibacterial activity test of papaya seed extract (Carica papaya L.) as an irrigation agent against Prevotella intermedia: Uji daya hambat ekstrak biji pepaya (Carica papaya L.) sebagai bahan irigasi terhadap bakteri Prevotella intermedia Alifa Nailah Suni; Indrya Kirana Mattulada; Syamsiah Syam; Nur Asmah; Kurniaty Pamewa
Makassar Dental Journal Vol. 15 No. 2 (2026): Volume 15 Issue 2 August 2026
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v15i2.1103

Abstract

Root canal infections are one of the main problems in endodontics, largely caused by Gram-negative anaerobic bacteria, like Prevotella intermedia, which is frequently found in necrotic pulp, periapical abscesses and chronic root canal infections. Root canal irrigation is essential for eliminating microorganisms; however, conventional agents such as sodium hypochlorite have several side effects, necessitating the use of safe and effective natural, one of which is pa-paya seed extract (Carica papaya L). This study investigated whether papaya seed extract, when used as an irrigant, can inhibit the growth of P.intermedia. This laboratory experimental study, employing a post-test control design, utilised samples of 5%, 20% and 30% papaya seed extract, alongside 2.5% sodium hypochlorite and distilled water as the control. The disc diffusion method was employed to assess inhibitory activity on Mueller-Hinton agar media inoculated with P.intermedia, with five replicates for each treatment. Data were analysed using one-way ANOVA and LSD post hoc tests. Pa-paya seed extract at all concentrations exhibited inhibitory activity against the growth of P.intermedia, the greatest was observed at the 15% concentration, followed by 10% and 5% (p<0.05). It is concluded that papaya seed extract effectively inhibits the growth of P.intermedia and has the potential to be used as an alternative irriga-gation agent in root canal treatment.
Co-Authors Alifa Nailah Suni Kurniaty Pamewa Nur Asmah Syamsiah Syam