Mekanisme Stres Psikologis Terhadap Frekuensi Dan Aktivitas Kejang Pada Pasien Epilepsi: Literatur Review

Firliana Ali Hasabi (Universitas Pendidikan Indonesia)
Ajriya Arumaisha Isfahani (Universitas Pendidikan Indonesia)
Alya Sukmawati Putri (Universitas Pendidikan Indonesia)
Azka Muhammad Aquilla Perdana (Universitas Pendidikan Indonesia)
Della Shintia Ajajira (Universitas Pendidikan Indonesia)
Ilma Ruari (Universitas Pendidikan Indonesia)
Juwita Kurnia Sari (Universitas Pendidikan Indonesia)
Rubanti Rahim Budiman (Universitas Pendidikan Indonesia)
Septiyani Ayusita Aprilia (Universitas Pendidikan Indonesia)
Syifa Ladya Putri (Universitas Pendidikan Indonesia)
Popi Sopiah (Universitas Pendidikan Indonesia)

Media Ilmu Kesehatan
Vol 15 No 1 (2026): Media Ilmu Kesehatan

Background: In addition to biological factors, psychological stress has an important role in influencing the frequency and severity of seizures through neuroendocrine and neural mechanisms.Objective: This study aims to examine and summarize the mechanisms that link psychological stress with the frequency and activity of seizures in epilepsy patients.Methods: This study uses a literature review method with a scoping review approach that refers to the PRISMA guidelines. Data sources were obtained from Google Scholar, Semantic Scholar, and PubMed with a range of 2021–2025. Article selection was carried out based on inclusion criteria and quality assessment using JBI.Results: Of the 711 articles found, four articles met the criteria. The results showed that psychological stress activates the hypothalamic–pituitary–adrenal (HPA) axis, increasing cortisol levels and disrupting the balance of neurotransmitters such as glutamate and GABA. This condition triggers an increase in the excitability of neurons which contributes to seizures.Conclusion: Psychological stress plays a role in increasing seizure activity in epilepsy through complex biological mechanisms.